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Pharmaceutical Chemistry Journal

, Volume 53, Issue 5, pp 419–422 | Cite as

Synthesis and In Vivo Evaluation of New Coumarin Conjugates as Potential Indirect-Action Anticoagulants

  • Nguyen Cong BangEmail author
  • A. Z. Abyshev
  • D. Yu. Ivkin
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A synthetic method for a series of new coumarin conjugates was developed. Their structures and physicochemical properties were determined by modern spectral methods (IR, NMR, ESI-MS). The anticoagulant activity was studied in vivo by determining the prothrombin time (PT). Compounds 4a (PT = 10.88 ± 0.56 sec) and 4b (13.10 ± 3.56 sec) were the most active and comparable to the reference drug warfarin (7.97 ± 1.93 sec).

Keywords

phenolic acids coumarins anticoagulant activity prothrombin time 

References

  1. 1.
    A. Z. Abyshev, E. M. Agaev, and R. A. Abyshev, Natural and Synthetic Coumarins and Flavonoids [in Russian], Prima, St. Petersburg, 2014, pp. 300 – 348.Google Scholar
  2. 2.
    A. Z. Abyshev and E. M. Agaev, Azerb. Pharm. Pharmacother. J., 12(1), 11 – 14 (2017).Google Scholar
  3. 3.
    A. Z. Abyshev, V. A. Gindin, E. V. Semenov, et al., Khim.-farm. Zh., 40(11), 27 – 30 (2006).Google Scholar
  4. 4.
    A. Z. Abyshev, I. K. Zhurkovich, D. Yu. Ivkin, and K. B. Nguen, Razrab. Regist. Lek. Sredstv, 2(19), 192 – 198 (2017).Google Scholar
  5. 5.
    A. N. Mironov (ed.), Handbook for Preclinical Drug Trials [in Russian], Vol. 1, Grif i K, Moscow, 2012, pp. 453 – 477.Google Scholar
  6. 6.
    D. Yu. Ivkin, A. V. Buryakina, I. L. Stepanova, and A. S. Ivkina, Obz. Klin. Farmakol. Lek. Ter., 11(1), 46 – 49 (2013).CrossRefGoogle Scholar
  7. 7.
    V. S. Gorbatenko, O. V. Shatalova, and A. S. Maslakov, Farmakoekon. Teor. Prakt., 4(1), 205 (2016).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Nguyen Cong Bang
    • 1
    Email author
  • A. Z. Abyshev
    • 1
  • D. Yu. Ivkin
    • 1
  1. 1.St. Petersburg State Chemical Pharmaceutical UniversitySt. PetersburgRussia

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