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Conjugates of Prostate-Specific Membrane Antigen Ligands with Antitumor Drugs

  • A. A. UspenskayaEmail author
  • A. É. Machulkin
  • A. G. Mazhuga
  • E. K. Beloglazkina
Article
  • 8 Downloads

Conjugates for targeted delivery that are based on low-molecular-mass prostate specific membrane antigen (PSMA) inhibitors are widely used and developed because of the deficiencies of existing methods for treating and diagnosing prostate cancer. The major classes of low-molecular-mass PSMA inhibitors, drug classes, and their mechanisms of action are discussed. Therapeutic conjugates for targeted delivery that are based on them are analyzed. Structural features of the linker that affect the biological activity and selectivity are identified.

Keywords

PSMA targeted delivery drug conjugates 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. A. Uspenskaya
    • 1
    Email author
  • A. É. Machulkin
    • 1
  • A. G. Mazhuga
    • 1
    • 2
  • E. K. Beloglazkina
    • 1
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.D. Mendeleev University of Chemical Technology of RussiaMoscowRussia

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