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Quantitative HPLC Determination of γ-Aminobutyric Acid Derivative Mefebut in Bioassays

  • L. A. Smirnova
  • A. F. RyabukhaEmail author
  • E. A. Suchkov
  • K. A. Kuznetsov
  • I. N. Tyurenkov
  • D. A. Bakulin
Article

A quantitative HPLC method was developed for analyzing mefebut in pharmacokinetic studies. The method was highly sensitive and selective and could be used for determinations in bioassays. The optimized sample-preparation method did not significantly influence the standard error of the quantitative determination.

Keywords

HPLC mefebut quantitative determination 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. A. Smirnova
    • 1
    • 2
  • A. F. Ryabukha
    • 1
    • 2
    Email author
  • E. A. Suchkov
    • 1
    • 2
  • K. A. Kuznetsov
    • 1
    • 2
  • I. N. Tyurenkov
    • 1
  • D. A. Bakulin
    • 1
  1. 1.Volgograd State Medical UniversityVolgogradRussia
  2. 2.Volgograd Medical Research CenterVolgogradRussia

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