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Pharmaceutical Chemistry Journal

, Volume 53, Issue 2, pp 129–133 | Cite as

Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives

  • L. A. KayukovaEmail author
  • A. B. Uzakova
  • G. P. Baitursynova
  • G. T. Dyusembaeva
  • Z. T. Shul’gau
  • A. E. Gulyaev
  • Sh. D. Sergazy
Article
  • 16 Downloads

New antidiabetic agents are being sought because of the global problem with diabetes. Amidoxime derivatives are known to have antidiabetic activity. β-Aminopropionamidoxime bases and pharmacologically acceptable salts of O-aroyl-β-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-3-β-(piperidin-1-yl and morpholin-1-yl)ethyl-1,2,4-oxadiazoles were screened in vitro for antidiabetic activity manifested as inhibition of α-amylase and α-glucosidase. Compounds with pronounced antidiabetic properties were identified. The series of 3,5-disubstituted 1,2,4-oxadiazoles were more active than the series of O-aroyl-β-aminopropionamidoximes. The results could be used for further in vivo screening of the antidiabetic properties of the most promising compounds with a preliminary assessment of their mean toxic doses in animals.

Keywords

bases and pharmacologically acceptable salts of O-aroyl-β-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-3-β-(piperidin-1-yl and morpholin-1-yl)ethyl-1,2,4-oxadiazoles in vitro antidiabetic screening for inhibition of α-amylase and α-glucosidase 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. A. Kayukova
    • 1
    Email author
  • A. B. Uzakova
    • 1
  • G. P. Baitursynova
    • 1
  • G. T. Dyusembaeva
    • 1
  • Z. T. Shul’gau
    • 2
  • A. E. Gulyaev
    • 2
    • 3
  • Sh. D. Sergazy
    • 2
    • 3
  1. 1.A. B. Bekturov Institute of Chemical SciencesAlmatyKazakhstan
  2. 2.National Center for BiotechnologyAstanaKazakhstan
  3. 3.Center for Life SciencesNazarbayev UniversityAstanaKazakhstan

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