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Pharmaceutical Chemistry Journal

, Volume 53, Issue 2, pp 113–117 | Cite as

Synthesis and Anti-Ischemic Activity in Rats of Substituted N-Benzyl 1,2,5-Trimethyl-, 2,2,6,6-Tetramethylpiperidyl-, and Tropylamines

  • L. M. KostochkaEmail author
  • S. A. Kryzhanovskii
  • I. B. Tsorin
  • M. B. Vititnova
  • V. N. Stolyaruk
Article
  • 26 Downloads

Series of benzylidene and benzyl derivatives of 1,2,5-trimethyl-, 2,2,6,6-tetramethylpiperidyl-, and tropylamines were synthesized and screened for anti-ischemic activity in rats. The lead compound was identified as 2,2,6,6-tetramethyl-N-(3,4,5-trimethoxybenzyl)piperidin-4-amine, the anti-ischemic activity of which was statistically significantly greater than that of the reference drug trimetazidine in a myocardial subendocardial ischemia model.

Keywords

piperidine tropane anti-ischemic activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. M. Kostochka
    • 1
    Email author
  • S. A. Kryzhanovskii
    • 1
  • I. B. Tsorin
    • 1
  • M. B. Vititnova
    • 1
  • V. N. Stolyaruk
    • 1
  1. 1.V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical SciencesMoscowRussia

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