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Pharmaceutical Chemistry Journal

, Volume 53, Issue 2, pp 108–112 | Cite as

Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity

  • I. B. ChernikovaEmail author
  • S. L. Khursan
  • M. Yu. Eropkin
  • M. S. Yunusov
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5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human flu viruses A/H3N2 and A/H1N1pdm09.

Keywords

5-fluorouracil 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil antiviral activity 

Notes

Acknowledgments

The work was performed on State Task Topic “Synthesis of biologically active heterocyclic and diterpenoid compounds” No. AAAA-A17 – 117011910025. Spectral and quantum-chemical parts used equipment at the Khimiya CUC, UfIC, RAS.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • I. B. Chernikova
    • 1
    Email author
  • S. L. Khursan
    • 1
  • M. Yu. Eropkin
    • 2
  • M. S. Yunusov
    • 1
  1. 1.Ufa Institute of Chemistry, Ufa Scientific Center, Russian Academy of SciencesUfaRussia
  2. 2.Research Institute of Influenza, Ministry of Healthcare of the Russian FederationSt. PetersburgRussia

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