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Physicochemical Properties of the Original Antidepressant GSB-106 and Development of a Method for the Analysis of GSB-106 Substance

  • A. V. TarasyukEmail author
  • N. M. Sazonova
  • A. N. Shumskii
  • A. L. Nekrashevich
  • P. I. Antipov
  • L. M. Gaevaya
  • L. N. Grushevskaya
  • S. V. Minaev
Article

Studies at the V. V. Zakusov Science Research Institute of Pharmacology have worked on the basis of the β-pleated structure of loop 4 of brain-derived neurotrophic factor (BDNF) to construct its dimeric peptide mimetic - GSB-106, bis-(N-monosuccinyl-L-serine-L-lysine) hexamethylenediamide. GSB-106 is being developed as an antidepressant with a BDNF-ergic mechanism of action. We report here studies of the physicochemical properties of GSB-106 and development of a method for analysis of GSB-106 substance. The main pharmacopeia quality indicators were determined and IR and NMR spectra were obtained from samples of substance. A method was developed for detecting contaminants in substance using TLC and HPLC.

Keywords

GSB-106 BDNF mimetics pharmaceutical analysis HPLC TLC IR spectroscopy 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. V. Tarasyuk
    • 1
    Email author
  • N. M. Sazonova
    • 1
  • A. N. Shumskii
    • 1
  • A. L. Nekrashevich
    • 1
  • P. I. Antipov
    • 1
  • L. M. Gaevaya
    • 1
  • L. N. Grushevskaya
    • 1
  • S. V. Minaev
    • 1
  1. 1.V. V. Zakusov Science Research Institute of PharmacologyMoscowRussia

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