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Pharmaceutical Chemistry Journal

, Volume 53, Issue 1, pp 65–70 | Cite as

Use of Gas Chromatomass Spectroscopy for Analysis of Salicylate Contents in Plasma from Patients with Cerebrovascular Diseases Taking Aspirin as Antiaggregant Therapy

  • D. A. AbaimovEmail author
  • L. R. Spavronskaya
  • A. A. Shabalina
  • M. M. Tanashyan
  • A. K. Sariev
STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL
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A chromatomass spectrometric method for assay of salicylic and acetylsalicylic acids in human plasma was developed and metrologically validated. The method measured salicylic and acetylsalicylic acid contents in plasma samples from 26 patients with cerebrovascular diseases (CVD) taking aspirin constantly at doses of 75 – 100 mg/day as antiaggregant therapy for primary or secondary prophylaxis of vascular events. Patients whose samples contained acetylsalicylic acid demonstrated more marked pharmacological responses to antiaggregant therapy.

Keywords

pharmacoresistance salicylates aspirin antiaggregants treatment monitoring mass spectroscopy gas chromatography derivatization 

References

  1. 1.
    L. Macchi, N. Sorel, and L. Christiaens, Cur. Pharm. Des., 12(2), 251 – 258 (2006).CrossRefGoogle Scholar
  2. 2.
    A. D. Michelson, M. Cattaneo, J. W. Eikelboom, et al., J. Thromb. Haemost., 3(6), 1309 – 1311 (2005).CrossRefGoogle Scholar
  3. 3.
    T. Grosser, S. Fries, J. A. Lawson, et al., Circulation, 127(3), 377 – 385 (2013).CrossRefGoogle Scholar
  4. 4.
    F. Kees, D. Jehnich, and H. Grobecker, J. Chromatogr. B, Biomed. Applicat., 677(1), 172 – 177 (1996).CrossRefGoogle Scholar
  5. 5.
    G. P. McMahon and M. T. Kelly, Anal. Chem., 70(2), 409 – 414 (1998).CrossRefGoogle Scholar
  6. 6.
    S. R. Polagani, N. R. Pilli, and V. Gandu, J. Pharm. Anal., 2(3), 206 – 213 (2012).CrossRefGoogle Scholar
  7. 7.
    S. Puram, R. Batheja, P. A. Vivekanand, et al., Asian. J. Chem., 28(11), 2403 – 2406 (2016).CrossRefGoogle Scholar
  8. 8.
    D. Sirok, M. Patfalusi, G. Szeleczky, et al., Microchemic. J., 136(1), 200 – 208 (2018).Google Scholar
  9. 9.
    Z. A. Suslina, V. G. Ionova, and E. G. Demina, Russian Federation Patent No. 2188419, A Means of Investigating the Antiaggregant Action of Drugs by Assessment of Platelet Aggregation [in Russian], Moscow (2002).Google Scholar
  10. 10.
    X. Chen, G. Bao, Y. Hua, et al., J. Molec. Neurosci. MN, 38(2), 201 – 206 (2009).CrossRefGoogle Scholar
  11. 11.
    K.-R. Kim, W.-H. Shim, Y.-J. Shin, et al., J. Chromatogr. A, 641(2), 319 – 327 (1993).CrossRefGoogle Scholar
  12. 12.
    A. Battezzati, G. Fiorillo, A. Spadafranca, et al., Anal. Biochem., 354(2), 274 – 278 (2006).CrossRefGoogle Scholar
  13. 13.
    S. Almeida, A. C. Spinola, A. Filipe, et al., Arzneimittel-Forschung, 57(5), 249 – 253 (2007).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • D. A. Abaimov
    • 1
    Email author
  • L. R. Spavronskaya
    • 1
  • A. A. Shabalina
    • 1
  • M. M. Tanashyan
    • 1
  • A. K. Sariev
    • 1
  1. 1.Neurology Science CenterMoscowRussia

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