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Pharmaceutical Chemistry Journal

, Volume 52, Issue 11, pp 959–964 | Cite as

DAD Based Stability Indicating RP-UPLC Method for Simultaneous Determination of Olmesartan Medoxomil and Amlodipine Besylate

  • Jayshri R. KeraiEmail author
  • Amitkumar J. Vyas
  • Bhupatsinh Vihol
  • Parth Patel
  • Ashok Patel
Article
  • 2 Downloads

Stability indicating RP-UPLC-DAD method for simultaneous determination of olmesartan medoxomil (OLM) and amlodipine besylate (AML) in tablet dosage forms has been developed. The method was fully validated, showing satisfactory data for all suitability parameters tested. The study of degradation products showed that OLM and ALM are more stable with respect to thermolysis and photolysis than under other stress-induced degradation conditions. The proposed stability indicating method can be applied in pharmaceutical analysis for drug stability monitoring and quality control.

Keywords

olmesartan medoxomil amlodipine besylate simultaneous determination stability indicating method RP-UPLC-DAD 

Notes

Acknowledgments

The authors are thankful to the Piramal Healthcare Ltd. for providing samples and laboratory facility for this research work.

References

  1. 1.
    United States Pharmacopeia 39 – National Formulary 34, The United State Pharmacopoeial Convention Inc., Rockville (2016), Vol. 2, pp. 2506 – 2507, 5134 – 5236.Google Scholar
  2. 2.
    S. C. Sweetman (Ed.), Martindale: The Complete Drug Reference, 36th Ed., The Pharmaceutical Press, London (2009), pp. 1214, 1361.Google Scholar
  3. 3.
    G. M. Niemeijer and J. T. Cleophas, Pharmaceuticals, 2, 125 – 133 (2009).CrossRefGoogle Scholar
  4. 4.
    B. R. Varma, P. K. Jampana, G. R. Babu, et al., Int. J. Pharm. Chem. Biol. Sci., 4, 69 – 3 (2014).Google Scholar
  5. 5.
    S. K. Shah, D. P. Kawade, A. J. Asnani, et al., Eur. J. Pharm. Med. Res., 3, 410 – 415 (2016).Google Scholar
  6. 6.
    D. Saxena, S. Damale, A. Joshi, et al., Int. J. Life Sci. Biotech. Pharm. Res., 3, 197 – 209 (2014).Google Scholar
  7. 7.
    A. Srinivas and Y. Sneha, Int. J. Pharm. Sci. Res., 164 – 167 (2015).Google Scholar
  8. 8.
    S. B. Wankhede, S. B. Wadkar, K. C. Raka, et al., Ind. J. Pharm. Sci., 28 (2009).Google Scholar
  9. 9.
    J. P. Vartak and S. N. Roy, Anal. Chem. Ind. J., 15, 111 – 116 (2015).Google Scholar
  10. 10.
    G. B. Kasawar and M. N. Farooqui, Orbital: Electronic J. Chem., 6, 130 – 141 (2014).Google Scholar
  11. 11.
    F. Pattan, K. H. Pavani, A. K. Kumar, et al., Ind. J. Res. Pharm. Biotech., 1, 692 – 697 (2013).Google Scholar
  12. 12.
    S. P. Bathula and K. P. Devani, Asian J. Pharm. Clin. Res., 5, 89 – 93 (2012).Google Scholar
  13. 13.
    W. Qi, Q. Zhao, J. Jiang, et al., J. Chromatogr. B, 27 – 34 (2013).Google Scholar
  14. 14.
    K. R. Patil, V. P. Rane, J. N. Sangshetti, et al., J. Chromatogr. Sci., 48, 601 – 608 (2010).CrossRefGoogle Scholar
  15. 15.
    P. S. Jain, M. K. Patel, A. P. Gorle, et al., J. Chromatogr. Sci., 50, 680–687 (2012).CrossRefGoogle Scholar
  16. 16.
    M. Rai and P. B. Kavde, Res. J. Pharm. Biol. Chem. Sci., 4, 560 (2013).Google Scholar
  17. 17.
    K. K. Kumar, C. K. Rao, G. Madhusudan, and K. Mukkanti, Am. J. Anal. Chem., 3, 50 – 58 (2012).CrossRefGoogle Scholar
  18. 18.
    ICH Guidelines, ICH Q2 (R1), Validation of Analytical Procedures: Text and Methodology. ICH, London (2005).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jayshri R. Kerai
    • 1
    Email author
  • Amitkumar J. Vyas
    • 1
  • Bhupatsinh Vihol
    • 1
  • Parth Patel
    • 1
  • Ashok Patel
    • 1
  1. 1.Gujarat Technological UniversityAhmedabadIndia

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