Synthesis, Antimicrobial Properties, and Toxicity of a Nanobiocomposite Based on Ag(0) Particles and Poly(1-Vinyl-1,2,4-Triazole)

  • L. M. SosedovaEmail author
  • M. A. Novikov
  • E. A. Titov
  • A. S. Pozdnyakov
  • S. A. Korzhova
  • T. G. Ermakova
  • G. F. Prozorova

The synthesis of a water-soluble polymer nanocomposite with Ag(0) particles encapsulated in a poly(1-vinyl-1,2,4-triazole) matrix is reported. The nanocomposite contains isolated spherical Ag(0) particles sized from 2 to 8 nm that are uniformly distributed in the polymer matrix and have a characteristic plasmonic absorption maximum at 412 nm. The new nanocomposite belongs to marginally hazardous category 4. The structural morphology of animal brain tissue is not disturbed after subacute intragastric injection. The bacteriostatic concentration of the nanocomposite varies in the range 0.5 – 32 μg/mL; bactericidal, 1 – 64 μg/mL.


polymer nanocomposites poly(1-vinyl-1,2,4-triazole) Ag(0) nanoparticles experimental research subacute administration white rats organ tissue morphology 


  1. 1.
    A. D. Pomogailo, A. S. Rozenberg, and I. E. Uflyand, Metal Nanoparticles in Polymers, Khimiya, Moscow (2000).Google Scholar
  2. 2.
    A. Tiwari, Recent Developments in Bio-Nanocomposites for Biomedical Applications, Nova Science Publishers, Inc., New York (2011).Google Scholar
  3. 3.
    D. P. Perez, Silver Nanoparticles, In-Teh, Vukovar (2010).Google Scholar
  4. 4.
    P. Broz, Polymer-Based Nanostructures: Medical Applications, RSC Publishing, Cambridge (2010).CrossRefGoogle Scholar
  5. 5.
    A. B. G. Lansdown, Adv. Pharmacol. Sci., 2010, 1 – 16 (2010).CrossRefGoogle Scholar
  6. 6.
    C. M. Powers, M. Palazuelos, B. M. Moudgil, and S. M. Roberts, Environ. Health Perspect., 119(1), 37 – 44 (2011).CrossRefGoogle Scholar
  7. 7.
    C. Stensberg, E. S. McLamore, D. M. Porterfield, et al., Nanomedicine (London, U. K.), 6(5), 879 – 898 (2011).CrossRefGoogle Scholar
  8. 8.
    S. K. Singh, K. Goswami, R. D. Sharma, et al., Int. J. Nanomed., 7, 1023 – 1030 (2012).Google Scholar
  9. 9.
    A. S. Pozdnyakov, A. I. Emel’yanov, T. G. Ermakova, and G. F. Prozorova, Vysokomol. Soedin., Ser. B, 56(2), 226 – 235 (2014).Google Scholar
  10. 10.
    A. S. Pozdnyakov, N. P. Kuznetsova, S. A. Korzhova, et al., Izv. Akad. Nauk, Ser. Khim., 6, 1440 – 1444 (2015).Google Scholar
  11. 11.
    A. S. Pozdnyakov, A. I. Emel’yanov, N. P. Kuznetsova, et al., Int. J. Nanomed., 11, 1295 – 1304 (2016).CrossRefGoogle Scholar
  12. 12.
    L. A. Tatarova, T. G. Ermakova, A. A. Berlin, et al., Vysokomol. Soedin., Ser. A, 24(10), 2205 – 2210 (1982).Google Scholar
  13. 13.
    A. N. Mironov, N. D. Bunyatyan, et al. (eds.), Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow (2012).Google Scholar
  14. 14.
    R. U. Khabriev, Handbook for Experimental (Preclinical) Studies of New Drugs [in Russian], 2nd Ed., Meditsina, Moscow (2005).Google Scholar
  15. 15.
    State Pharmacopoeia of the Russian Federation, 12th Ed., Part 1, Nauchnyi Tsentr Ekspertizy Sredstv Meditsinskogo Primeneniya (SCEEMP), Moscow (2008).Google Scholar
  16. 16.
    G. E. Afinogenov, V. V. Kopeikin, and E. F. Panarin, RU Pat. 2,128,047, Mar. 27, 1999.Google Scholar
  17. 17.
    V. V. Lopeikin, E. F. Panarin, Yu. G. Santuryan, et al., RU Pat. 2,088,234, Jul. 27, 1996.Google Scholar
  18. 18.
    V. V. Kopeikin and P. P. Rodionov, Experience with clinical studies and use of the latest domestic silver-containing bactericidal preparation poviargol. Guide and information for physicians [in Russian], Inst. Vysokomol. Soedin., RAS, St. Petersburg (1998).Google Scholar
  19. 19.
    S. E. Rzheusskii, A. G. Dovnar, and V. V. Kugach, Vestn. BGMU, 14, 120 – 126 (2015).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. M. Sosedova
    • 1
    Email author
  • M. A. Novikov
    • 1
  • E. A. Titov
    • 1
  • A. S. Pozdnyakov
    • 2
  • S. A. Korzhova
    • 2
  • T. G. Ermakova
    • 2
  • G. F. Prozorova
    • 2
  1. 1.East-Siberian Medico-Ecological Research InstituteAngarskRussia
  2. 2.A. E. Favorsky Irkutsk Institute of ChemistrySiberian Branch, Russian Academy of SciencesIrkutskRussia

Personalised recommendations