Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring

  • F. A. Khaliullin
  • Yu. V. Shabalina
  • A. V. Samorodov
  • F. Kh. Kamilov
  • G. A. Timirkhanova
  • D. Z. Murataev
Article
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Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 – 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 – 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.

Keywords

xanthines thietanes antiaggregatory activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • F. A. Khaliullin
    • 1
  • Yu. V. Shabalina
    • 1
  • A. V. Samorodov
    • 1
  • F. Kh. Kamilov
    • 1
  • G. A. Timirkhanova
    • 1
  • D. Z. Murataev
    • 1
  1. 1.Bashkir State Medical UniversityUfaRussia

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