Neuropsychology Review

, Volume 29, Issue 2, pp 166–180 | Cite as

(Neuro)Psychological Interventions for Non-Motor Symptoms in the Treatment of Patients with Parkinson’s Disease: a Systematic Umbrella Review

  • Hanna KamplingEmail author
  • Lisa K. Brendel
  • Oskar Mittag


Conducted in a multidisciplinary and multimodal setting, the main objectives of neuropsychological treatment are to improve cognition, alleviate affective disorders, and to promote activities and participation. This article reviews the evidence on therapeutic or educative interventions based on psychological principles for patients with Parkinson’s disease. The electronic bibliographic databases MEDLINE, PsycINFO, PSYNDEX, and CINAHL were systematically searched for meta-analyses on psychological interventions for patients with Parkinson’s disease, published from January 2000 to June 2018. We extracted psychological interventions, non-motor outcomes, effect sizes, confidence intervals, and I2 heterogeneity statistics. In addition, we rated the level of evidence on an intervention’s effectiveness regarding a specific outcome. We identified 15 meta-analyses out of 1084 search results and identified a broad variety of psychological interventions for non-motor symptoms in patients with Parkinson’s disease. In total, 48 outcome-intervention-pairs were extracted. Psychotherapy, mind and body interventions, and cognitive training are promising treatment approaches when addressing cognition, depression, and QoL in patients with Parkinson’s disease. The available evidence on the effectiveness of psychological interventions in the treatment of symptoms in patients with Parkinson’s disease is very heterogeneous. Still, our review reveals that some interventions are appropriate and effective for a variety of symptoms. Primary studies are not considered in this review, resulting in the omission of potentially relevant findings. Further high-quality research is needed to confirm the existing evidence and to explore the potential of psychological interventions for patients with Parkinson’s disease.


Parkinson’s disease Neuropsychology Non-motor outcomes Psychological interventions Alternative and complementary therapy Systematic review Umbrella review 



activities of daily living


cognitive-behavioral therapy


confidence interval


minimally clinically important changes


mean difference


Parkinson’s disease


Parkinson’s Disease Questionnaire




quality of life


randomized controlled trials


standardized mean difference


Unified Parkinson’s Disease Rating Scale


Author’s Contribution

HK and OM contributed significantly to the conception, organization and execution of the research project. All authors contributed significantly to the analysis and interpretation of data. HK and LKB drafted the article. OM significantly contributed to the writing. All authors revised it critically for important intellectual content, and approved the final version.


This work was supported by the German Statutory Pension Insurance (Deutsche Rentenversicherung Bund) under Grant 0423/00–40–64-50-18. The founding source was not involved in data collection, analysis, or interpretation of the data, in writing the manuscript, or in the decision to submit this article for publication.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Supplementary material

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ESM 1 (PDF 33 kb)
11065_2019_9409_MOESM2_ESM.pdf (32 kb)
ESM 2 (PDF 31 kb)
11065_2019_9409_MOESM3_ESM.pdf (339 kb)
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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Section of Health Care Research and Rehabilitation Research, Faculty of MedicineMedical Center – University of FreiburgFreiburgGermany

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