Neurochemical Research

, Volume 44, Issue 12, pp 2695–2707 | Cite as

The Story of Nanoparticles in Differentiation of Stem Cells into Neural Cells

  • Vajihe Asgari
  • Amir Landarani-Isfahani
  • Hossein Salehi
  • Noushin Amirpour
  • Batool Hashemibeni
  • Saghar Rezaei
  • Hamid BahramianEmail author


Stem cells have been long looked at as possible therapeutic vehicles in regenerative medicine largely due to their multi-lineage differentiation potential and paracrine actions. Therefore, development of new procedures for the differentiation of stem cells into different cell types holds great potential for opening new opportunities in regenerative medicine. In addition to various methods for inducing stem cell differentiation, the utilization of nanomaterials for differentiation of stem cells has recently received considerable attention and has become a potential tool for such purpose. Multiple lines of evidence revealed that nanomaterial-based scaffolds, inorganic nanoparticles (NPs), and biodegradable polymers have led to significant progress in regulation of stem cell differentiation. Several studies indicated that different NPs including selenium, gold, graphene quantum dots (QDs) and silica could be employed for the regulation of differentiation of stem cells such as human mesenchymal stem cells (hMSCs). In addition, magnetic core–shell NPs could be applied for the regulation of neural stem cell (NSC) differentiation. Taken together, these findings suggested that NPs are potential candidates which could be utilized for the differentiation of stem cells into various cell types such as neural cells. Herein, we summarized the application of NPs for differentiation of stem cells into various cells in particular neural cells.


Nanomaterial Nanoparticles Stem cells Differentiation Neural cells 



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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Vajihe Asgari
    • 1
  • Amir Landarani-Isfahani
    • 2
  • Hossein Salehi
    • 1
  • Noushin Amirpour
    • 1
  • Batool Hashemibeni
    • 1
  • Saghar Rezaei
    • 1
  • Hamid Bahramian
    • 1
    Email author
  1. 1.Department of Anatomical Sciences, Faculty of MedicineIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of ChemistryUniversity of IsfahanIsfahanIran

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