Neurochemical Research

, Volume 44, Issue 9, pp 2230–2236 | Cite as

Functional Recovery Occurs Even After Partial Remyelination of Axon-Meshed Median and Ulnar Nerves in Mice

  • Ana Elisa SpeckEmail author
  • Jocemar Ilha
  • Daniel Fernandes Martins
  • Franciane Bobinski
  • Ana Paula Luiz
  • Adair Roberto Soares dos Santos
  • Alessandra Swarowsky
  • Aderbal Silva AguiarJr.
Original Paper


Upper limb nerve injuries are common, and their treatment poses a challenge for physicians and surgeons. Experimental models help in minimum exploration of the functional characteristics of peripheral nerve injuries of forelimbs. This study was conducted to characterize the functional recovery (1, 3, 7, 10, 14, and 21 days) after median and ulnar nerve crush in mice and analyze the histological and biochemical markers of nerve regeneration (after 21 days). Sensory–functional impairments appeared after 1 day. The peripheral nerve morphology, the nerve structure, and the density of myelin proteins [myelin protein zero (P0) and peripheral myelin protein 22 (PMP22)] were analyzed after 21 days. Cold allodynia and fine motor coordination recovery occurred on the 10th day, and grip strength recovery was observed on the 14th day after injury. After 21 days, there was partial myelin sheath recovery. PMP22 recovery was complete, whereas P0 recovery was not. Results suggest that there is complete functional recovery even with partial remyelination of median and ulnar nerves in mice.


Median nerve Ulnar nerve Axonotmesis Strength Myelin 



This work was supported by grants from CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasília, DF, Brazil) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasília, DF, Brazil). ARSS and ASAJr are CNPq fellows. The authors have no personal or financial conflict of interest.

Compliance with Ethical Standards

Conflict of interest

The authors have no personal or financial conflict of interest.

Supplementary material

Supplementary file1 (MP4 18374 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ana Elisa Speck
    • 1
    • 2
    • 6
    Email author
  • Jocemar Ilha
    • 1
    • 2
  • Daniel Fernandes Martins
    • 3
    • 4
  • Franciane Bobinski
    • 3
    • 4
  • Ana Paula Luiz
    • 3
  • Adair Roberto Soares dos Santos
    • 3
  • Alessandra Swarowsky
    • 1
    • 2
  • Aderbal Silva AguiarJr.
    • 5
  1. 1.Programa de Pós-Graduação em Fisioterapia, Centro do Ciências da Saúde e do EsporteUniversidade do Estado de Santa Catarina (UDESC)FlorianópolisBrazil
  2. 2.Laboratório do Sistema Neuromotor (LASIN), Departamento de FisioterapiaUniversidade do Estado de Santa Catarina (UDESC)FlorianópolisBrazil
  3. 3.Laboratório de Neurobiologia da Dor e Inflamação (LANDI), Departamento de Ciências FisiológicasUniversidade Federal de Santa Catarina (UFSC)FlorianópolisBrazil
  4. 4.Laboratório de Neurociências Experimental (LaNEx), Programa de Pós-Graduação em Ciências da SaúdeUniversidade do Sul de Santa Catarina (UNISUL)PalhoçaBrazil
  5. 5.Research Group on Biology of Exercise, Department of Health SciencesUFSC-Federal University of Santa CatarinaAraranguáBrazil
  6. 6.Centro de Ciências BiológicasUniversidade Federal de Santa Catarina (UFSC) Campus TrindadeFlorianópolisBrazil

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