Neurochemical Research

, Volume 43, Issue 9, pp 1714–1722 | Cite as

NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders

  • Chengyan Chu
  • Yue Gao
  • Xiaoyan Lan
  • Aline Thomas
  • Shen LiEmail author
Review Paper


The neural cell adhesion molecule (NCAM) plays a pivotal role in the development and maintenance of the nervous system via homophilic (NCAM–NCAM) and heterophilic (NCAM-other molecules) interactions. Many synthetic peptides have been engineered to mimic these interactions and induce NCAM-downstream signaling pathways. Such NCAM mimetics have displayed neuritogenic and neuroprotective properties, as well as synaptic modulation in vitro and in vivo. Furthermore, they have been used successfully in preclinical studies to treat neurological disorders including stroke, traumatic brain injury and Alzheimer’s disease. This review focuses on recent progress in the development of NCAM mimetic peptides, in particular, on establishing C3, plannexin, and FGL as therapeutic candidates for neurological disorders.


Neural cell adhesion molecule Bioactive peptides Mimetic peptides Fibroblast growth factor receptor Neurological disorders 



The work was fund by the National Natural Science Foundation of China (81300985), Natural Science Foundation of Liaoning Province (2015020549) and Dalian Municipal Health and Family Planning Project (1711014).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  1. 1.Department of NeurologyDalian Municipal Central Hospital Affiliated to Dalian Medical UniversityDalianChina
  2. 2.Russell H. Morgan Department of Radiology and Radiological Science, Division of MR ResearchThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of Neurological RehabilitationThe Second Hospital of Dalian Medical UniversityDalianChina

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