Neurochemical Research

, Volume 43, Issue 4, pp 796–805 | Cite as

Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ1–42-Treated Rats

  • Xiaoyu Song
  • Bo Liu
  • Lingyu Cui
  • Biao Zhou
  • Lu Liu
  • Weiwei Liu
  • Guodong Yao
  • Mingyu Xia
  • Toshihiko Hayashi
  • Shunji Hattori
  • Yuko Ushiki-Kaku
  • Shin-ichi Tashiro
  • Takashi Ikejima
Original Paper
  • 113 Downloads

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterized by a cascade of pathologic changes. A widely discussed theory indicates that amyloid β (Aβ) peptides are the causative agents of AD. Silibinin, a flavonoid derived from milk thistle, is well known for its hepato-protective activities and we have reported the neuroprotective effects of silibinin. In this study, we investigated the role of estrogen receptors (ERs) in silibinin’s neuroprotective effect on Aβ1−42-injected rats. Results of Morris water maze and novel object-recognition tests demonstrated that silibinin significantly attenuated Aβ1−42-induced memory impairment. Silibinin attenuated ERs and PI3K-Akt pathways, as well as modulated mitogen-activated protein kinases in the hippocampus of Aβ1−42-injected rats. Taken together, silibinin is a potential candidate in the treatment of Alzheimer’s disease.

Keywords

Silibinin Amyloid Estrogen receptor Memory impairment Alzheimer’s disease 

Notes

Acknowledgements

This research was supported by National Natural Science Foundation of China (No. 81273517).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Xiaoyu Song
    • 1
    • 2
  • Bo Liu
    • 1
  • Lingyu Cui
    • 1
  • Biao Zhou
    • 1
  • Lu Liu
    • 1
  • Weiwei Liu
    • 1
  • Guodong Yao
    • 1
    • 5
  • Mingyu Xia
    • 1
  • Toshihiko Hayashi
    • 1
  • Shunji Hattori
    • 3
  • Yuko Ushiki-Kaku
    • 3
  • Shin-ichi Tashiro
    • 4
  • Takashi Ikejima
    • 1
  1. 1.China–Japan Research Institute of Medical and Pharmaceutical SciencesShenyang Pharmaceutical UniversityShenyangChina
  2. 2.Medical Research CenterShenzhen University Health Science CenterShenzhenChina
  3. 3.Nippi Research Institute of BiomatrixTorideJapan
  4. 4.Department of Medical Education & Primary CareKyoto Prefectural University of MedicineKyoto City, KyotoJapan
  5. 5.School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education)Shenyang Pharmaceutical UniversityShenyangChina

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