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Neurophysiology

, Volume 51, Issue 2, pp 72–76 | Cite as

Effects of a Gut Microbiome Toxin, p-Cresol, on the Contents of the NMDA2B Receptor Subunit in the Nucl. Accumbens of Rats

  • G. Tevzadze
  • E. Zhuravliova
  • M. Meparishvili
  • T. Lortkipanidze
  • L. Shanshiashvili
  • Z. Kikvidze
  • D. MikeladzeEmail author
Article
  • 6 Downloads

The effects of p-cresol on the levels of subunit 2RB of NMDA receptors and also of AMPA and GABAA receptors in the nucl. accumbens (NAc) of rats were studied. As was found, the content of the NR2B subunit of NMDA glutamate receptors is increased in p-cresol-treated rats, and this elevation is abrogated after intranasal administration of oxytocin. These effects of oxytocin were partly reversed after i.p. injections of naltrexone. We suggest that interplay between mesolimbic glutamatergic, oxytocinergic, and opioidergic systems in the NAc may be important in the development of p-cresol-dependent neurological disorders.

Keywords

gut microbiome p-cresol autism NMDA receptor oxytocinergic and opioidergic systems 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • G. Tevzadze
    • 1
  • E. Zhuravliova
    • 2
    • 4
  • M. Meparishvili
    • 2
  • T. Lortkipanidze
    • 2
  • L. Shanshiashvili
    • 2
    • 4
  • Z. Kikvidze
    • 3
  • D. Mikeladze
    • 2
    • 4
    Email author
  1. 1.4-D Research Institute, Institute of Chemical BiologyIlia State UniversityTbilisiGeorgia
  2. 2.Institute of Chemical BiologyIlia State UniversityTbilisiGeorgia
  3. 3.Institute of Ethnobiology and SocioecologyIlia State UniversityTbilisiGeorgia
  4. 4.Beritashvili Center of Experimental BiomedicineTbilisiGeorgia

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