Aerobic Physical Training Protects the Rat Brain Against Exercise-Heat Related Oxidative Damage through the Increased Expression of HSP70
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We explored the mechanism underlying the improvement of tolerance to exercise-heat stress through physical training at a moderate temperature. Rats were randomly divided into an aerobic exercise (AE) group and a control (C) group. Rats in the former group were subjected during 5 weeks for AE in a cool environment (20°C). The oxidative damage level in the brain to AE rats after both 1-h-long heat exposure and exhaustive exercise in heat and the rate of core temperature rise were lower than those in the control (P < 0.05). The expression level of HSP70 in the motor cortex and the exhaustion time in group AE were found to be significantly greater compared to those in group C (P < 0.05). Our results indicate that the enhanced expression of HSP70 may be an important factor for physical training in a cool environment, and this factor improves tolerance to exercise-heat stress.
Keywordsaerobic physical training oxidative damage brain temperature conditions exercise-heat stress HSP70
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- 5.K. B. Pandolf, “Effects of physical training and cardiorespiratory physical fitness on exercise-heat tolerance: recent observations,” Med. Sci. Sports, 11, No. 1, 60–65 (1978).Google Scholar
- 10.D. L. Wang, X. L. Liu, and D. C. Qiao, “Modulatory effect of subthalamic nucleus on the development of fatigue during exhausting exercise: An in vivo electrophysiological and microdialysis study in rats,” J. Sport. Sci. Med., 11, No. 2, 286–293 (2012).Google Scholar
- 11.G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, San Diego (1997).Google Scholar
- 22.Z. Radak, A. W. Taylor, H. Ohno, and S. Goto, “Adaptation to exercise-induced oxidative stress: from muscle to brain,” Exerc. Immunol. Rev., 7, 90–107(2001).Google Scholar