Effects of Vitamin E on the Synthesis of Phospholipids and Brain Functions in Old Rats
We examined the effects of supplementation of old rats with vitamin E (alpha-tocopherol, αTPh, acetate) on phospholopid (PL) metabolism in the brain and cognitive functions of these animals. Intragastric administration of αTPh to 24-month-old rats for 14 days resulted in a noticeable increase in the level of newly synthesized phosphatidylserine (PS) in the hippocampus of experimental animals, as compared with control rats. At the same time, there was a decrease in the [14C] phosphatidylcholine (PC) content in the hippocampus of experimental rats vs. controls. Changes in the PL levels observed in the hippocampus of experimental animals due to αTPh administration were associated with an increased number of active avoidances and a decreased latent period of these events within acquisition of the respective conditioned reflex in a shuttle box. The data obtained provide evidence that αTPh is a potent modulator of PL metabolism in the hippocampus and functions of the latter at old age.
Keywordsaging hippocampus vitamin E phosphatidylcholine (PC) phosphatidylserine (PS) cognitive functions
Unable to display preview. Download preview PDF.
- 9.V. Chandra, J. Jasti, P. Kaur, et al., “First structural evidence of a specific inhibition of phospholipase A2 by alpha-tocopherol (vitamin E) and its implications in inflammation: crystal structure of the complex formed between phospholipase A2 and alpha-tocopherol at 1.8 A resolution,” J. Mol. Biol., 320, No. 2, 215-222 (2002).CrossRefPubMedGoogle Scholar
- 28.B. F. Serinkan, Y. Y. Tyurina, H. Babu, et al., “Vitamin E inhibits anti-Fas-induced phosphatidylserine oxidation but does not affect its externalization during apoptosis in Jurkat T cells and their phagocytosis by J774A.1 macrophages,” Antioxid. Redox Signal., 6, No. 2, 227-236 (2004).CrossRefPubMedGoogle Scholar
- 37.N. A. Crivello, I. H. Rosenberg, G. E. Dallal, et al., “Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation,” Neurochem. Int., 47, No. 8, 573-579 (2005).CrossRefPubMedGoogle Scholar
- 38.V. Mansat, G. Laurent, T. Levade, et al., “The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin,” Cancer Res., 57, No. 23, 5300-5304 (2005).Google Scholar