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Phase II study of weekly carboplatin in pretreated adult malignant gliomas

  • Veronica Villani
  • Andrea Pace
  • Antonello Vidiri
  • Antonio Tanzilli
  • Francesca Sperati
  • Irene Terrenato
  • Carosi Mariantonia
  • Beatrice Casini
  • Giulio Metro
  • Marta Maschio
  • Koudriavtseva Tatiana
  • Francesco Cognetti
  • Alessandra FabiEmail author
Clinical Study
  • 24 Downloads

Abstract

Purpose

Patients with relapse of recurrent glioma have a poor outcome and limited treatment options. The aim of this study is to investigate the clinical benefit and tolerability of weekly intravenous administration of carboplatin-based monotherapy in adult glioma patients who had progressed from previous chemotherapy lines based on temozolomide and nitrosoureas.

Methods

This was a single-arm, phase II study. Eligibility criteria included progressive or recurrent glioma after radiotherapy and chemotherapy-based treatments and Karnofsky performance status (KPS) > 60.

Results

Thirty-two patients (median age 43.5 years) were enrolled to receive weekly carboplatin monotherapy in an intravenous method of administration. The median duration of response was 7.3 months with an overall disease control rate of 31.3%. Median progression-free survival was 2.3 months while overall survival was 5.5 months. Pre-treatment with corticosteroids (i.e. dexamethasone) was associated to clinical benefit in 43.8% of patients. Patients achieving clinical benefit exhibited a longer progression-free survival (4.6 vs. 1.5 months; p > 0.001) and overall survival (7.9 vs. 3.2 months; p = 0.041) compared with those not achieving clinical benefit.

Conclusions

Our findings show that single agent, weekly, intravenous administration of carboplatin may have a role in patients with recurrent glioma and suggest that pre-treatment with corticosteroids may confer survival benefit.

Keywords

Glioblastoma Recurrence Carboplatin Progression-free survival Corticosteroid use 

Notes

Acknowledgements

Editorial assistance was provided by Luca Giacomelli, PhD, Chiara Degirolamo, PhD, and Aashni Shah, from Polistudium (Milan, Italy); this assistance was supported by internal funds.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human and/or animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Regina Elena Institute, Rome, Italy) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Veronica Villani
    • 1
  • Andrea Pace
    • 1
  • Antonello Vidiri
    • 2
  • Antonio Tanzilli
    • 1
  • Francesca Sperati
    • 3
  • Irene Terrenato
    • 3
  • Carosi Mariantonia
    • 4
  • Beatrice Casini
    • 4
  • Giulio Metro
    • 6
  • Marta Maschio
    • 1
  • Koudriavtseva Tatiana
    • 1
  • Francesco Cognetti
    • 5
  • Alessandra Fabi
    • 5
    Email author
  1. 1.Neuro-Oncology UnitIRCCS - Regina Elena National Cancer InstituteRomeItaly
  2. 2.Service of NeuroradiologyIRCCS - Regina Elena National Cancer InstituteRomeItaly
  3. 3.Biostatistic UnitIRCCS - Regina Elena National Cancer InstituteRomeItaly
  4. 4.Division of NeuropathologyIRCCS - Regina Elena’ National Cancer InstituteRomeItaly
  5. 5.Division of Medical OncologyIRCCS - Regina Elena National Cancer InstituteRomeItaly
  6. 6.Ospedale Santa Maria Della Misericordia Azienda Ospedaliera Di PerugiaPerugiaItaly

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