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Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function

  • Oluwaseun O. Akinduro
  • Larry B. Lundy
  • Alfredo Quinones-Hinojosa
  • Victor M. Lu
  • Daniel M. Trifiletti
  • Vivek Gupta
  • Robert E. WharenEmail author
Clinical Study

Abstract

Introduction

Subtotal resection (STR) of vestibular schwannoma (VS) tumors remains controversial and little is known regarding post-operative volume changes.

Methods

Authors retrospective reviewed the medical records from January 1st 2002 to January 1st 2018, for all patients who had undergone primary STR of large VS at a single tertiary academic institution.

Results

Our series consists of 34 patients with a mean age of 53.9 (median 53; range 21–87) years that had STR of their VS tumor. The mean pre-operative tumor diameter and volume was 3.9 cm (median 3.0 cm; range 1.6–6.0 cm) and 11.7 cm3 (median 9.6 cm3; range 2.8–44.3 cm3), respectively, with a mean extent of resection of 86% (median 90%; range 53–99%). The mean radiographic and clinical follow-up was 40 months (range 6–120 months) and 51 months (range 7–141 months), respectively. 85% of patients had optimal House–Brackmann (HB) scores (Grade 1 & 2) immediately post-operatively, and 91% at 1 year; 94% of patients had normal (HB 1) at last follow-up. There was significant regression of residual tumor volume at 1 year (p = 0.006) and 2 years (p = 0.02), but not at 3 years (p = 0.08), when compared to the prior year. There was significant regression of size over time, with a mean slope estimate of − 0.70 units per year (p < 0.001).

Conclusion

Excellent clinical facial nerve outcomes can be obtained with STR of large VS tumors. Maximal reduction in tumor size occurs at 2-year post-operatively. Thus, in patients undergoing surgery for large VS, STR and a “watch and wait” strategy is a reasonable treatment option that may optimize facial nerve outcomes.

Keywords

Acoustic neuroma Vestibular schwannoma Subtotal resection Volume reduction Stereotactic radiosurgery 

Abbreviations

HB

House–Brackmann

MRI

Magnetic resonance imaging

VS

Vestibular schwannoma

SRS

Stereotactic radiosurgery

STR

Subtotal resection

Notes

Acknowledgements

We thank David Hodge of the Mayo Clinic Florida statistics department for his assistance with analyzing this data.

Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

This study was approved by our institutional review board as minimal risk, thus negating need for written consent from each patient.

Supplementary material

11060_2019_3157_MOESM1_ESM.docx (80 kb)
Supplementary material 1 (DOCX 79 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Oluwaseun O. Akinduro
    • 1
  • Larry B. Lundy
    • 2
  • Alfredo Quinones-Hinojosa
    • 1
  • Victor M. Lu
    • 5
  • Daniel M. Trifiletti
    • 4
  • Vivek Gupta
    • 3
  • Robert E. Wharen
    • 1
    Email author
  1. 1.Department of Neurologic SurgeryMayo Clinic FloridaJacksonvilleUSA
  2. 2.Department of OtolaryngologyMayo Clinic FloridaJacksonvilleUSA
  3. 3.Department of NeuroradiologyMayo Clinic FloridaJacksonvilleUSA
  4. 4.Department of Radiation OncologyMayo Clinic FloridaJacksonvilleUSA
  5. 5.Department Neurologic SurgeryMayo ClinicRochesterUSA

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