Journal of Neuro-Oncology

, Volume 140, Issue 1, pp 99–106 | Cite as

Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center

  • Qi Jia
  • Chao Liu
  • Jian Yang
  • Yong Ji
  • Haifeng Wei
  • Tielong Liu
  • Xinghai YangEmail author
  • Cheng YangEmail author
  • Jianru XiaoEmail author
Clinical Study



Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB.


Clinical data of 13 consecutive CB patients who received surgical treatment in our center between January 2006 and December 2016 were reviewed retrospectively. Recurrence-free survival (RFS) was estimated by Kaplan–Meier method and Log-rank test.


The 13 CB patients included 9 men and 4 women with a mean age of 32 years. The lesions were located in the cervical spine in 2 cases, thoracic spine in 5 cases, and lumbar spine in 6 cases. All the patients were treated surgically using either curettage, piecemeal total resection, or TES. Postoperative radiotherapy was administered in 2 cases. The mean follow-up period was 41.6 months. Relapse occurred in 3 (23.1%) cases, resulting in one death in 60 months. The mean RFS duration was 28.7 months.


CB predominantly affects males and various age groups. Spinal CB more commonly involves the thoracic and lumbar segments. Spinal CB usually appears as an aggressive and destructive bony lesion with a soft tissue mass on imaging, forming compression on the spinal cord in some cases. Recurrence is not uncommon for spinal CB. Total resection, especially TES, has been confirmed as a powerful method to control the disease, while curettage is more likely to associate with local recurrence. Radiotherapy does not seem to reduce local recurrence.


Chondroblastoma Spine Aggressive tumor Retrospective study Total en bloc spondylectomy 


Compliance with ethical standards

Conflict of interest

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript. No conflict of interest exists in the submission of this manuscript for all authors, and manuscript is approved by all authors for publication


This work was supported by Grants from National Key Research and Development Program of China (2016YFC0902100).


  1. 1.
    Konishi E, Nakashima Y, Mano M et al (2017) Chondroblastoma of extra-craniofacial bones: clinicopathological analyses of 103 cases. Pathol Int 67:495–502CrossRefGoogle Scholar
  2. 2.
    Bloem JL, Mulder JD (1985) Chondroblastoma: a clinical and radiological study of 104 cases. Skeletal Radiol 14:1–9CrossRefGoogle Scholar
  3. 3.
    Venkatasamy A. Chenard MP, Massard G et al (2017) Chondroblastoma of the thoracic spine: a rare location: case report with radiologic-pathologic correlation. Skeletal Radiol 46:367–372. CrossRefGoogle Scholar
  4. 4.
    Ilaslan H, Sundaram M, Unni KK (2003) Vertebral chondroblastoma. Skeletal Radiol 32:66–71. CrossRefGoogle Scholar
  5. 5.
    Vialle R, Feydy A, Rillardon L et al (2005) Chondroblastoma of the lumbar spine: report of two cases and review of the literature. J Neurosurg 2:596–600Google Scholar
  6. 6.
    Kurt AM, Unni KK, Sim FH et al (1989) Chondroblastoma of bone. Hum Pathol 20:965–976CrossRefGoogle Scholar
  7. 7.
    Sohn SH, Koh SA, Kim DG et al (2009) A case of spine origin chondroblastoma metastasis to lung. Cancer Res Treat 41(4):241–244. CrossRefGoogle Scholar
  8. 8.
    Osman W, Zaoui A, Soumaya BA et al (2014) Chondroblastoma of the lower thoracic spine: a case report and review of the literature. Am J Med Case Rep 2(4):78–81Google Scholar
  9. 9.
    Ehalt W, Ratzenhofer M (1967) Zur Kasuistik des Gutartigen Chondroblastomes. Z Orthop 102(4):625–629Google Scholar
  10. 10.
    Wigwicki T (1969) Dziaka: cshondroblastoma. WIAD LA 22(15):1387–1392Google Scholar
  11. 11.
    Wisniewski M, Toker C, Anderson PJ et al (1973) Chondroblastoma of the cervical spine: case report. J Neurosurg 38(6):763–766CrossRefGoogle Scholar
  12. 12.
    Brasse F, Hoeffel JC, Montaut J et al (1985) A proposd’un chrondroblastome vertebral. Rev Chir Orthop 71(6):389–392Google Scholar
  13. 13.
    Edel G, Ueda Y, Nakanishi J et al (1992) Chondroblastoma of bone: a clinical, radiological, light and immunohistochemical study. Virchows Arch A 421(4):355–366CrossRefGoogle Scholar
  14. 14.
    Akai M, Tateishi A, Machinami R et al (1986) Chondroblastoma of the sacrum: case report. Acta Orthop Scand 57(4):378–381CrossRefGoogle Scholar
  15. 15.
    Hoeffel JC, Brasse F, Schmitt M et al (1987) About one case of vertebral chondroblastoma. Pediatr Radiol 17(5):392–396CrossRefGoogle Scholar
  16. 16.
    Howe JW, Baumgard S, Jochum TR et al (1988) Case report 449: chondroblastoma involving C5 and C6. Skelet Radiol 17(1):52–55CrossRefGoogle Scholar
  17. 17.
    Kurth AA, Warzecha J, Rittmeister M et al (2000) Recurrent chondroblastoma of the upper thoracic spine: a case report and review of the literature. Arch Orthop Trauma Surg 120(9):544–557CrossRefGoogle Scholar
  18. 18.
    Attar A, Ugur HC, Caglar YS et al (2001) Chondroblastoma of the thoracic vertebra. J Clin Neurosci 8(1):59–60CrossRefGoogle Scholar
  19. 19.
    Leung LY, Shu SJ, Chan MK et al (2001) Chondroblastoma of the lumbar vertebra. Skelet Radiol 30(12):710–713CrossRefGoogle Scholar
  20. 20.
    Shin BJ, Yun TK, Lim KC et al (2001) Chondroblastoma of the first lumbar vertebra: a case report. J Korean Soc Spine Surg 8:90–95CrossRefGoogle Scholar
  21. 21.
    Nishida J, Kato S, Murakami H et al (2003) Tetraparesis caused by chondroblastoma of the cervical spine: a case report. Spine, 28(9), E173–E178Google Scholar
  22. 22.
    Chung OM, Yip SF, Ngan KC et al (2003) Chondroblastoma of the lumbar spine with cauda equina syndrome. Spinal Cord 41:359–364CrossRefGoogle Scholar
  23. 23.
    Lee YH, Shin DA, Kim KN et al (2005) A case of thoracic vertebral chondroblastoma, treated with 3-D image resection and reconstruction. J Korean Neurosurg Soc 37, 154–156Google Scholar
  24. 24.
    Kim SA, Cho KJ, Park YK et al (2011) Chondroblastoma of the lumbar spine: a case report and review of the literature. Korean J Pathol 45:532–536CrossRefGoogle Scholar
  25. 25.
    Fletcher CDM, Bridge JA, Hogendoorn et al (2011) WHO classification of tumours of soft tissue and bone. 4th edn. Lyon: IARCGoogle Scholar
  26. 26.
    Frankel HL, Hancock DO, Hyslop G et al (1969) The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia: I. Paraplegia 7(3):179–192Google Scholar
  27. 27.
    Boriani S, Weinstein JN, Biagini R (1997) Primary bone tumors of the spine: terminology and surgical staging. Spine 22(9):1036–1044CrossRefGoogle Scholar
  28. 28.
    Tomita K, Kawahara N, Murakami H et al (2006) Total en bloc spondylectomy for spinal tumors: improvement of the technique and its associated basic background. J Orthop Sci 11(1):3–12CrossRefGoogle Scholar
  29. 29.
    Unni KK (ed) (1996) Dahlin’s textbook of bone tumors, 5th edn. Lippincott-Raven, Philadelphia/New YorkGoogle Scholar
  30. 30.
    Suneja R, Grimer RJ, Belthur M et al (2005) Chondroblastoma of bone: long-term results and functional outcome after intralesional curettage. J Bone Joint Surg Br 87:974–978CrossRefGoogle Scholar
  31. 31.
    Lin PP, Thenappan A, Deavers MT et al (2005) Treatment and prognosis of chondroblastoma. Clin Orthop Relat Res 438:103–109CrossRefGoogle Scholar
  32. 32.
    Shooshtarizadeh T, Rahimi M, Movahedinia S (2016) P63 expression as a biomarker discriminating giant cell tumor of bone from other giant cell-rich bone lesions. Pathology. Google Scholar
  33. 33.
    Tathe SP, Parate SN, Jaiswal KN et al (2018) Intraoperative crush smear cytology of vertebral chondroblastoma: a diagnostic challenge. Diagn Cytopathol 46:79–82. CrossRefGoogle Scholar
  34. 34.
    Angelini A, Hassani M, Andreas F et al (2017) Mavrogenis: chondroblastoma in adult age. Eur J Orthop Surg Traumatol 27:843–849. CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Orthopedic Oncology, Shanghai Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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