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Neuroscience and Behavioral Physiology

, Volume 50, Issue 1, pp 126–136 | Cite as

Behavior of Rats with High and Low Levels of Freezing in Defensive Situations and on Selection of Food Reinforcement

  • I. V. PavlovaEmail author
  • M. P. Rysakova
  • M. I. Zaichenko
  • N. D. Broshevitskaya
Article
  • 3 Downloads

Behavior in rats with different levels of freezing in a classical defensive conditioned reflex was compared on acquisition of conditioned passive and active avoidance reflexes and on selection of food reinforcement of different values. Rats with prolonged freezing acquired the passive avoidance reflex better and retained it longer during extinction than animals with shorter freezing. At the same time, the active avoidance reflex in the shuttle box was acquired more easily by animals with short periods of freezing. Rats with prolonged freezing preferred a delayed and more valuable reinforcement in the model of choosing food reinforcements of different values (low level of impulsivity), while animals with short freezing preferred the low-value reinforcement without a delay (high level of impulsivity). The thresholds of pain sensitivity were no different in rats of the different groups. Thus, rats with prolonged freezing demonstrated a passive behavioral strategy in defensive situations and a low level of impulsivity, while rats with short freezing used an active behavioral strategy and showed a high level of impulsivity.

Keywords

classical defensive reflex passive avoidance reflex active avoidance reflex pain sensitivity threshold selection of food reinforcement of different values (delay discounting) 

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References

  1. 1.
    A. I. Vaido, I. V. Zhdanova, and N. V. Shiryaeva, “The emotional resonance reaction in rats with different levels of nervous system arousal,” Zh. Vyssh. Nerv. Deyat., 37, No. 3, 575–577 (1987).Google Scholar
  2. 2.
    D. A. Zhukov, The Psychogenetics of Stress. Behavioral and Endocrine Correlates of Genetic Determinants of Stress Reactivity in an Uncontrollable Situation, SPbTsNTI, St. Petersburg (1997).Google Scholar
  3. 3.
    D. A. Zhukov and E. P. Vinogradova, “Pain sensitivity thresholds in rats genetically selected for the rate of acquisition of active avoidance,” Zh. Vyssh. Nerv. Deyat., 47, No. 1, 167–169 (1997).Google Scholar
  4. 4.
    M. I. Zaichenko, G. Kh. Merzhanova, and A. V. Demina, “Studies of the behavior of ‘impulsive’ and ‘self-controlled’ animal using the ‘emotional resonance’ method,” Zh. Vyssh. Nerv. Deyat., 60, No. 2, 192–200 (2010).Google Scholar
  5. 5.
    M. I. Zaichenko, G. L. Vanetsian, and G. Kh. Merzhanova, “Differences in the behavior of impulsive and self-controlled rats in studies in the open field and light-dark box tests,” Zh. Vyssh. Nerv. Deyat., 61, No. 3, 340–350 (2011).Google Scholar
  6. 6.
    M. I. Zaichenko, A. V. Sharkova, G. A. Grigor’yan, and G. Kh. Merzhanova, “Signal memory in high impulsive rats in an eight-arm radial maze is better than in low impulsive animals,” Zh. Vyssh. Nerv. Deyat., 66, No. 5, 600–610 (2016).Google Scholar
  7. 7.
    A. A. Levandovskaya, M. I. Zaichenko, G. Kh, Merzhanova, and S. V. Salozhin, “Assessment of exploratory activity and anxiety in rats with differences in the extent of impulsive behavior,” Zh. Vyssh. Nerv. Deyat., 63, No. 6, 719–729 (2013).Google Scholar
  8. 8.
    L. M. Livanova, I. P. Levshina, L. V. Nozdracheva, et al., “Prophylactic influence of negatively charged air ions in acute stress in rats with different typological behavioral features,” Zh. Vyssh. Nerv. Deyat., 46, No. 3, 564–570 (1996).Google Scholar
  9. 9.
    I. V. Pavlova and M. P. Rysakova, “Signs of anxiety in Wistar rats on acquisition of conditioned reflex fear,” Zh. Vyssh. Nerv. Deyat., 65, No. 6, 719–735 (2015).Google Scholar
  10. 10.
    I. V. Pavlova and M. P. Rysakova, “The influences of administration of serotonin 5-HT1A receptor ligands into the amygdala on the behavior of rats with different signs of conditioned reflex fear,” Zh. Vyssh. Nerv. Deyat., 66, No. 6, 710–724 (2016).Google Scholar
  11. 11.
    I. V. Pavlova, M. P. Rysakova, and M. I. Sergeeva, “Effects of blockade of D1 and D2 receptors in the basolateral amygdala on the behavior of rats with high and low levels of anxiety and fear,” Zh. Vyssh. Nerv. Deyat., 65, No. 4, 471–485 (2015).Google Scholar
  12. 12.
    M. Yu. Stepanichev, A. O. Tishkina, M. R. Novikova, et al., “Effects of chronic combined stress: changes in the behavior of rats with different reactions to novelty,” Zh. Vyssh. Nerv. Deyat., 66, No. 5, 611– 625 (2016).Google Scholar
  13. 13.
    N. V. Shiryaeva, A. I. Vaido, E. S. Petrov, et al., “Behavior of rats with different levels of nervous system arousal in an open fi eld,” Zh. Vyssh. Nerv. Deyat., 37, No. 6, 1064–1069 (1987).Google Scholar
  14. 14.
    X. L. An, X. G. Zheng, J. Liang, and Y. J. Bai, “Corticosterone combined with intramedial prefrontal cortex infusion of SCH 23390 impairs the strong fear response in high-fear-reactivity rats,” Psychol. J., 2, No. 1, 1-10 (2013).CrossRefGoogle Scholar
  15. 15.
    D. C. Blanchard and R. J. Blanchard, “Ethoexperimental approaches to the biology of emotion,” Annu. Rev. Psychol., 39, 43–68 (1988).CrossRefGoogle Scholar
  16. 16.
    A. Borta and R. K. Schwarting, “Inhibitory avoidance, pain reactivity, and plus-maze behavior in Wistar rats with high versus low rearing activity,” Physiol. Behav., 84, No. 3, 387–396 (2005).CrossRefGoogle Scholar
  17. 17.
    D. E. Bush, F. Sotres-Bayon, and J. E. LeDoux, “Individual differences in fear: isolating fear reactivity and fear recovery phenotypes,” J. Trauma Stress, 20, No. 4, 413–422 (2007).Google Scholar
  18. 18.
    J. Coyner, J. L. McGuire, C. C. Parker, et al., “Mice selectively bred for High and Low fear behavior show differences in the number of pMAPK (p44/42 ERK) expressing neurons in lateral amygdale following Pavlovian fear conditioning,” Neurobiol. Learn. Mem, 112, 195–203 (2014).CrossRefGoogle Scholar
  19. 19.
    V. Deroche, P. V. Piazza, M. Le Moal, and H. Simon, “Individual differences in the psychomotor effects of morphine are predicted by reactivity to novelty and influenced by corticosterone secretion,” Brain Res., 623, No. 2, 341–344 (1993).CrossRefGoogle Scholar
  20. 20.
    S. Diaz-Moran, M. Palencia, C. Mont-Cardona, et al., “Coping style and stress hormone responses in genetically heterogeneous rats: comparison with the Roman rat strains,” Behav. Brain Res., 228, No. 1, 203–210 (2012).CrossRefGoogle Scholar
  21. 21.
    A. Gozzi, A. Jain, A. Giovannelli, et al., “A neural switch for active and passive fear,” Neuron, 67, No. 4, 656–666 (2010).CrossRefGoogle Scholar
  22. 22.
    J. A. Gray, The Psychology of Fear and Stress, Cambridge Univ. Press, Cambridge (1987).Google Scholar
  23. 23.
    J. M. Koolhaas, “Coping style and immunity in animals: making sense of individual variation,” Brain Behav. Immun., 22, No. 5, 662–667 (2008).CrossRefGoogle Scholar
  24. 24.
    J. Koolhaas, S. F. de Boer, B. Buwalda, and K. van Reenen, “Individual variation in coping with stress: a multidimensional approach of ultimate and proximate mechanisms,” Brain Behav. Evol., 70, No. 4, 218–226 (2007).CrossRefGoogle Scholar
  25. 25.
    J. E. Ledoux, A. Sakaguchi, and D. J. Reis, “Strain differences in fear between spontaneously hypertensive and normotensive rats,” Brain Res., 277, No. 1, 137–143 (1983).CrossRefGoogle Scholar
  26. 26.
    M. Lehner, E. Taracha, A. Skorzewska, et al., “Behavioral, immunocytochemical and biochemical studies in rats differing in their sensitivity to pain,” Behav. Brain Res., 171, No. 2, 189–198 (2006).CrossRefGoogle Scholar
  27. 27.
    M. Lehner, A. Wislowska-Stanek, P. Maciejak, et al., “The relationship between pain sensitivity and conditioned fear response in rats,” Acta Neurobiol. Exp., 70, No. 1, 56–66 (2010).Google Scholar
  28. 28.
    L. M. Rorick, P. R. Finn, and J. E. Steinmetz, “Heart rate reactivity an HAD and LAD rats during Pavlovian fear conditioning,” Integr. Physiol. Behav. Sci., 39, No. 1, 24–41 (2004).CrossRefGoogle Scholar
  29. 29.
    K. P. Satinder and K. D. Hill, “Effects of genotype and postnatal experience on activity, avoidance shock threshold, and open-field behavior of rats,” J. Comp. Physiol. Psychol., 86, 363–374 (1974).CrossRefGoogle Scholar
  30. 30.
    R. Shuhama, C. V. Del-Ben, S. R. Loureiro, and F. G. Graeff, “Animal defense strategies and anxiety disorders,” An. Acad. Bras. Cienc., 79, No. 1, 97–109 (2007).CrossRefGoogle Scholar
  31. 31.
    A. Skorzewska, M. Lehner, A. Wislowska-Stanek, et al., “Midazolam treatment before re-exposure to contextual fear reduces freezing behavior and amygdale activity differentially in high-and low-anxiety rats,” Pharmacol. Biochem. Behav., 129, 34–44 (2015).Google Scholar
  32. 32.
    O. Stiedl, J. Radulovic, R. Lohmann, et al., “Strain and substrain differences in context-and tone-dependent fear conditioning of inbred mice,” Behav. Brain Res., 104, No. 1–2, 1–12 (1999).CrossRefGoogle Scholar
  33. 33.
    K. Szklarczyk, M. Korostynski, S. Golda, et al., “Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in mice,” Neuroscience, 330, 121–137 (2016).CrossRefGoogle Scholar
  34. 34.
    A. A. Zozulya, M. V. Gabaeva, O. Y. Sokolov, et al., “Personality, coping style, and constitutional neuroimmunology,” J. Immunotoxicol., 5, No. 2, 221–225 (2008).CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • I. V. Pavlova
    • 1
    Email author
  • M. P. Rysakova
    • 1
  • M. I. Zaichenko
    • 1
  • N. D. Broshevitskaya
    • 1
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia

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