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Correlation of the Genetic Profile and Characteristics of Rehabilitation after Ischemic Stroke

  • E. V. Kovaleva
  • B. M. Doronin
  • V. V. MorozovEmail author
  • Yu. V. Seryapina
  • S. G. Markova
Article

Objectives. To study the influences of carriership of polymorphisms of lipid peroxidation system genes on the risk of developing ischemic stroke (IS) and on the prognosis of disease outcome after rehabilitation treatment. Materials and methods. A total of 746 patients with IS and 500 patients of a control group without impairments to the cerebrovascular circulation were genotyped to identify the polymorphic variants of six genes of the lipid peroxidation system – HIF1a C1772T, ApoE ε2/ε3/ε4, MnSOD C47T, GPX-1 C599T, BDNF G196T, and p22phox C242T. Results and conclusions. The C1772T HIF1 polymorphism was found to be a statistically significant risk factor for the development of IS with an odds ratio of 1.702 (p < 0.05). The GPX-1 C599T and BDNF G196T gene polymorphisms showed a tendency to be the more widespread genotypes among patients with degradation of neurological status. These data lead to the conclusion that the polymorphic variants of genes affect not only the risk of developing stroke, but also the results of the treatment and rehabilitation of patients.

Keywords

ischemic stroke risk factor lipid peroxidation polymorphism HIF1a medical rehabilitation 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. V. Kovaleva
    • 1
  • B. M. Doronin
    • 2
  • V. V. Morozov
    • 1
    Email author
  • Yu. V. Seryapina
    • 1
  • S. G. Markova
    • 1
  1. 1.Institute of Chemical Biology and Basic Medicine, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State Medical University, Russian Ministry of HealthNovosibirskRussia

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