Correlation of the Genetic Profile and Characteristics of Rehabilitation after Ischemic Stroke

  • E. V. Kovaleva
  • B. M. Doronin
  • V. V. MorozovEmail author
  • Yu. V. Seryapina
  • S. G. Markova

Objectives. To study the influences of carriership of polymorphisms of lipid peroxidation system genes on the risk of developing ischemic stroke (IS) and on the prognosis of disease outcome after rehabilitation treatment. Materials and methods. A total of 746 patients with IS and 500 patients of a control group without impairments to the cerebrovascular circulation were genotyped to identify the polymorphic variants of six genes of the lipid peroxidation system – HIF1a C1772T, ApoE ε2/ε3/ε4, MnSOD C47T, GPX-1 C599T, BDNF G196T, and p22phox C242T. Results and conclusions. The C1772T HIF1 polymorphism was found to be a statistically significant risk factor for the development of IS with an odds ratio of 1.702 (p < 0.05). The GPX-1 C599T and BDNF G196T gene polymorphisms showed a tendency to be the more widespread genotypes among patients with degradation of neurological status. These data lead to the conclusion that the polymorphic variants of genes affect not only the risk of developing stroke, but also the results of the treatment and rehabilitation of patients.


ischemic stroke risk factor lipid peroxidation polymorphism HIF1a medical rehabilitation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    B. V. Titov, N. A. Matveeva, M. Yu. Martynov, and O. O. Favorova, “Ischemic stroke as a complex polygenic disease,” Mol. Biol. (Mosk.), 49, No. 2, 224 (2015), Scholar
  2. 2.
    T. Hachiya, Y. Kamatani, A. Takahashi, et al., “Genetic predisposition to ischemic stroke: A polygenic risk score,” Stroke, 48, No. 2, 253–258 (2017), Scholar
  3. 3.
    M. G. Parfenov, B. V. Titov, M. A. Sudomoina, et al., “Complex analysis of genetic predisposition to ischemic stroke in Russians,” Mol. Biol. (Mosk.), 43, No. 5, 937–945 (2009).CrossRefGoogle Scholar
  4. 4.
    B. V. Titov, R. M. Barsova, M. Yu. Martynov, et al., “Polymorphic variants of genes encoding interleukin-6 and fibrinogen, the risk of ischemic stroke, and fi brinogen levels,” Mol. Biol. (Mosk.), 46, No. 1, 93–102 (2012).CrossRefGoogle Scholar
  5. 5.
    O. Yu. Bushueva, T. A. Stetskaya, A. V. Polonikov, and V. P. Ivanov, “Association of the 640A>G polymorphism of the CYBA gene with the risk of developing ischemic stroke in Russians in Central Russia,” Zh. Nevrol. Psikhiat.115, No. 9–2, 38–41 (2015), Scholar
  6. 6.
    V. N. Butikov, A. S. Zaslavskii, and G. O. Penina, “Ischemic stroke in the inhabitants of the European north: analysis of risk factors,” Arter. Gipertenz., 16, No. 4, 373–377 (2010).CrossRefGoogle Scholar
  7. 7.
    B. V. Titov, N. A. Matveeva, M. Yu. Martynov, and O. O. Favorova, “Multilocus analysis of associations of polymorphic variants of the genes of the infl ammation system with ischemic stroke in Russians,” Mol. Biol. (Mosk.), 50, No. 4, 674–684 (2016), Scholar
  8. 8.
    Z. Qu, F. Su, Y. Zhu, et al., “A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population,” Int. J. Clin. Exp. Med., 8, No. 11, 21343–21350 (2015), eCollection, PMID: 26885075, PMCID: PMC4723920.Google Scholar
  9. 9.
    A. Kumar, S. Misra, P. Kumar, et al., “Association between beta-fibrinogen C148T gene polymorphism and risk of ischemic stroke in a North Indian population: A case-control study,” Pulse (Basel), 4, No. 4, 165–171 (2017), Scholar
  10. 10.
    X. Liu, R. Zhu, Q. Li, and Z. He, “Lack of association between MCP-1 -2518A/G polymorphism and ischemic stroke: From a case-control study to an updated meta-analysis,” J. Neurol. Sci., 15, No. 373, 113–115 (2017), Scholar
  11. 11.
    V. L. C. Pereira, V. C. I. Castellanos, and S. F. A. Sieger, “Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in Colombian population: a case control study,” Colomb Med (Cali), 47, No. 4, 189–195 (2016), PMID: 28293042, PMCID: PMC5335859.Google Scholar
  12. 12.
    M. Bendeck, “Targeting pericellular proteolysis in vascular disease,” Circ. Res., 91, No. 10, 861–862 (2002), Scholar
  13. 13.
    Case-Control Studies. Tests for Deviation from Hardy–Weinberg Equilibrium and Tests for Association,, acc. Nov. 24, 2017.
  14. 14.
    T. M. Stanne, A. Tjärnlund-Wolf, S. Olsson, et al., “Genetic variation at the BDNF locus: evidence for association with long-term outcome after ischemic stroke,” PLoS One, 9, No. 12, e114156 (2014), Scholar
  15. 15.
    N. N. Strambovskaya, “The prognostic role of polymorphic variants of candidate genes in patients with ischemic stroke in the Trans-Baikal,” Fundam. Issled., 1, No. 1, 140–144 (2015).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. V. Kovaleva
    • 1
  • B. M. Doronin
    • 2
  • V. V. Morozov
    • 1
    Email author
  • Yu. V. Seryapina
    • 1
  • S. G. Markova
    • 1
  1. 1.Institute of Chemical Biology and Basic Medicine, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State Medical University, Russian Ministry of HealthNovosibirskRussia

Personalised recommendations