Effects of Acute Cooling on Expression of Genes for Thermosensitive TRP Ion Channels in the Hypothalamus
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Acute cooling of the body was found to have different effects on the expression of thermosensitive TRP ion channel genes in the hypothalamus which depended on the cooling rate. Slow cooling of the body affected the expression of genes for two types of thermosensitive TRP ion channels in the hypothalamus – TRPV3 and TRPM8. Changes in gene expression did not occur simultaneously – Trpv3 gene expression increased at the peak of cooling, when thermoregulatory reactions develop, while that of the Trpm8 gene increased on restoration of body temperature after cooling. Rapid cooling at the peak of the thermoregulatory reaction had no effect on expression of genes for thermosensitive TRP ion channels in the hypothalamus. On restoration of body temperature after rapid cooling, activity in the Trpm8 gene in the hypothalamus increased. Thus, acute temperature exposure affected processes occurring at the level of the genome and dynamic changes in the expression of TRP ion channel genes in the hypothalamus may be one of the mechanisms of adaptation to changes in temperature conditions.
KeywordsTRP ion channels gene expression hypothalamus cold
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