Dynamics of Postischemic Changes in the Microcirculation in the Rat Cerebral Cortex
Postischemic changes in the circulation appear primarily in the microcirculatory system. There are few studies of the cerebral microcirculation after ischemia and these are scattered and fragmentary. The aim of the present work was to conduct a complex study of the dynamics of the main parameters of the microcirculation (tissue perfusion with blood, blood saturation, and tissue oxygen consumption) in the cerebral cortex of rats 1 h and 2, 7, 14, and 21 days after ischemia induced by occlusion of both carotid arteries for 12 min with simultaneous controlled hypotension to a level of 45 ± 3 mmHg. The hyperperfusion seen 1 h after ischemia was found to be replaced by degradation of the microcirculation in rat brain tissue lasting the next three weeks, due to suppression of the active mechanisms controlling blood flow and decreases in vessel tone. These features were accompanied by stagnation of the blood, decreases in cortical tissue oxygen consumption, and decreases in blood oxygen saturation.
Keywordscerebral ischemia microcirculation perfusion saturation
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