Cellular-Molecular Mechanisms of the Regulation of Angiogenesis in the Brain

  • V. M. ChertokEmail author
  • N. V. Zakharchuk
  • A. G. Chertok

This review presents data on the cellular-molecular mechanisms regulating angiogenesis associated with the vascular endothelium. Existing concepts hold that the control of angiogenesis involves activated endothelial cells and their precursors (progenitor cells), which synthesize and release angiogenic molecules with different chemical structures and mechanisms of biological action, but all allowing these cells to control each stage of angiogenesis directly or indirectly. Balanced functioning of the system of molecular stimulators and inhibitors of angiogenesis is particularly important for the brain, as excessive formation of blood vessels, like inadequate development of blood vessels, leads in certain conditions to rapid and irreversible changes in nervous tissue. Post-operative neurorepair cannot occur without adequate reperfusion of the injured part of the brain, which can be supported by timely stimulation of angiogenesis, while intensification of this process in tumors, conversely, has adverse consequences. Tumor growth and metastasis are significantly linked with increases in the level of vascularization of malignant tissue, while blockade of angiogenesis is not infrequently the only productive method of limiting tumor growth. However, we have insufficient knowledge of the mechanisms regulating angiogenesis in the brain at the cellular-molecular level in physiological conditions and pathology, so angiogenic influences do not always produce the expected effect.


brain angiogenesis cellular-molecular mechanisms of regulation poststroke reperfusion brain tumors 


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Authors and Affiliations

  • V. M. Chertok
    • 1
    Email author
  • N. V. Zakharchuk
    • 1
  • A. G. Chertok
    • 1
  1. 1.Pacific State Medical UniversityVladivostokRussia

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