Neuroscience and Behavioral Physiology

, Volume 49, Issue 3, pp 370–372 | Cite as

Characteristics of CART Peptide-Immunopositive Cells in the Subventricular Zone of the Brain

  • A. V. AkhmadeyevEmail author
  • L. B. Kalimullina
  • A. A. Nurutdinov
  • Ye. N. Yelizaryeva

Objectives. To study the cytoarchitectonics, neuronal organization, and distribution of CART peptide-immunopositive cells in the subventricular zone of the brain. Materials and methods. Studies were performed on frontal brain sections from rats (n = 18) using the Nissl, Golgi, and immunohistochemical methods with antibodies to CART (55–102). Specimens were examined by light microscopy. Results. CART peptide-immunopositive cells were detected in the subventricular zone of the inferior horn of the lateral ventricle in the paleoamygdala. These cells had round-oval bodies, one or two short processes, and in terms of their neuronal organization were neuroblastomorphic neurons. Conclusions. These data provide evidence that cells in the subventricular zone of the paleoamygdala express CART peptide in health. This determines the high efficacy of neuroregenerative treatment with this substance.


paleoamygdala amygdaloid body of the brain CART peptide neuroregeneration ischemic stroke 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. V. Akhmadeyev and L. B. Kalimullina, “Expression of CART peptide in paleoamygdala neurons and its relationship with sex hormone levels,” Byull. Eksperim. Biol. Med., 147, No. 4, 394–396 (2009).CrossRefGoogle Scholar
  2. 2.
    A. V. Akhmadeyev and L. B. Kalimullina, “The doctrine of A. L. Polenov regarding the evolution of the neuroendocrine system – the key to understanding the significance of CART-peptide,” in: Neuroendocrinology-2015: Proc. IX All-Russ. Conf., IEFiB RAN, St. Petersburg (2015), pp. 30–31.Google Scholar
  3. 3.
    T. A. Leontovich, Neuronal Organization of the Subcortical Formations of the Forebrain, Meditsina, Moscow (1978).Google Scholar
  4. 4.
    A. Alvarez-Buylla and J. Garcia-Verdugo, “Neurogenesis in adult subventricular zone,” J. Neurosci., 22, 629–634 (2002).CrossRefGoogle Scholar
  5. 5.
    Y. Luo, H. Shen, H. Liu, et al., “CART peptide induces neuroregeneration in stroke rats,” J. Cereb. Blood Flow Metab., 33, 300–310 (2013).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. V. Akhmadeyev
    • 1
    Email author
  • L. B. Kalimullina
    • 1
  • A. A. Nurutdinov
    • 1
  • Ye. N. Yelizaryeva
    • 1
  1. 1.Department of Safety and Environmental ConservationBashkir State UniversityUfaRussia

Personalised recommendations