Neuroscience and Behavioral Physiology

, Volume 49, Issue 1, pp 54–59 | Cite as

The Antioxidant, Anti-Inflammatory, and Sedative Effects of Melatonin: Results of Clinical Trials

  • D. I. BurchakovEmail author
  • Yu. B. Uspenskaya

We present published data (clinical trials and systematic reviews) of the antioxidant and anti-inflammatory effects of melatonin. The results of studies published in recent years on these effects in humans and animals are summarized. Melatonin has been shown to protect the cardiovascular system from damage induced by ischemia/reperfusion when given promptly; it has a neuroprotective effect in neonates after asphyxia; it is an effective agent in the complex treatment of irritable bowel syndrome and inflammatory gut disorders (Crohn’s disease and ulcerative colitis). It is also regarded as a premedication agent, decreasing anxiety for surgery, potentially allowing prescription of benzodiazepines to be avoided.


melatonin ischemia/reperfusion premedication gut diseases 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Sechenov First Moscow State Medical University (Sechenov University)MoscowRussia

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