Efficacy of Reslip (doxylamine) in Acute Insomnia: A Multicenter, Open, Comparative, Randomized Trial
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Objectives. To assess the efficacy of Reslip (doxylamine) in acute insomnia in comparison with Donormyl. Materials and methods. A multicenter, open, randomized trial was conducted at six medical centers in the Russian Federation. The trial included 60 patients with acute insomnia aged 30–59 years, who were randomized into two groups. Patients of one group received Reslip and those of the other received Donormyl at the same dose and regime. Results. Most patients in both groups experienced improvements in the clinical signs of acute insomnia. The severity of insomnia, daytime drowsiness, and reductions in quality of sleep in both groups showed highly significant decreases. Side effects from the drugs were rare and in most cases did not require treatment termination. There were no significant differences in treatment results with Reslip and Donormyl. Conclusions. Short-term treatment with doxylamine formulations had marked positive clinical effects in acute insomnia, combined with satisfactory tolerance by the patients. The Russian doxylamine formulation Reslip had clinical efficacy and tolerance which were no different from those of Donormyl and can be used in clinical practice for the treatment of acute insomnia.
Keywordsdoxylamine Reslip acute insomnia treatment of insomnia treatment of sleeplessness
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- 2.A. V. Golenkov and M. G. Poluektov, “The prevalence of sleep disorders in the population of Chuvashia (results of a complete interview study)” Zh. Nevrol. Psikhiat., 111, No. 6, 64–67 (2011).Google Scholar
- 3.International Classification of Sleep Disorders, American Academy of Sleep Medicine Darien, IL (2014), 3rd ed.Google Scholar
- 5.B. B. Brown and H. W. Werner, “The effects of decapryn succinate, a new antihistamine agent, in some natural and acquired hypersensitivities in animals; 2-[alpha-dimethylaminoethoxy)-alpha-methylbenzyl] pyridine succinate,” Ann. Allergy, 6, No. 2, 122–130 (1948).Google Scholar
- 6.Ya. I. Levin, and K. N. Strygin, “Donormyl in the treatment of insomnia,” Lech. Nerv. Bolez., 6, No. 2, 16 (2005).Google Scholar
- 9.A. A. Smirnov, A. V. Gustov, and O. Yu. Zheltova, “Efficacy of the use of Donormyl in the treatment of insomnias in patients with cerebral ischemia,” Zh. Nevrol. Psikhiat., 106, No. 3, 56–57 (2006).Google Scholar