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Neuroscience and Behavioral Physiology

, Volume 49, Issue 1, pp 45–47 | Cite as

Efficacy of Reslip (doxylamine) in Acute Insomnia: A Multicenter, Open, Comparative, Randomized Trial

  • A. Yu. Mel’nikovEmail author
  • S. Yu. Lavrik
  • L. F. Bikbulatova
  • I. G. Raginene
  • Ya. A. Ivanova
  • A. V. Zakharov
Article
  • 6 Downloads

Objectives. To assess the efficacy of Reslip (doxylamine) in acute insomnia in comparison with Donormyl. Materials and methods. A multicenter, open, randomized trial was conducted at six medical centers in the Russian Federation. The trial included 60 patients with acute insomnia aged 30–59 years, who were randomized into two groups. Patients of one group received Reslip and those of the other received Donormyl at the same dose and regime. Results. Most patients in both groups experienced improvements in the clinical signs of acute insomnia. The severity of insomnia, daytime drowsiness, and reductions in quality of sleep in both groups showed highly significant decreases. Side effects from the drugs were rare and in most cases did not require treatment termination. There were no significant differences in treatment results with Reslip and Donormyl. Conclusions. Short-term treatment with doxylamine formulations had marked positive clinical effects in acute insomnia, combined with satisfactory tolerance by the patients. The Russian doxylamine formulation Reslip had clinical efficacy and tolerance which were no different from those of Donormyl and can be used in clinical practice for the treatment of acute insomnia.

Keywords

doxylamine Reslip acute insomnia treatment of insomnia treatment of sleeplessness 

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. Yu. Mel’nikov
    • 1
  • S. Yu. Lavrik
    • 2
  • L. F. Bikbulatova
    • 3
  • I. G. Raginene
    • 4
  • Ya. A. Ivanova
    • 5
  • A. V. Zakharov
    • 6
  1. 1.Scientific Clinical Center for OtorhinolaryngologyFederal Medical Biological AgencyMoscowRussia
  2. 2.Irkutsk State Medical Academy of Postgraduate EducationIrkutskRussia
  3. 3.Medical StandardSpecialized Medical Clinics GroupUfaRussia
  4. 4.RenovatsioCenter for Esthetic MedicineKrasnoyarskRussia
  5. 5.Research Institute of Physiology and Basic MedicineNovosibirskRussia
  6. 6.Samara State Medical UniversitySamaraRussia

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