The Dorsal and Ventral Hippocampus Have Different Reactivities to Proinflammatory Stress: Corticosterone Levels, Cytokine Expression, and Synaptic Plasticity
- 1 Downloads
The dorsal and ventral parts of the hippocampus are functionally and morphologically nonidentical, and differences include stress reactivity. The present report describes the first study of the influence of proinflammatory stress induced by administration of lipopolysaccharide on the functional state and levels of the stress hormone corticosterone and proinflammatory cytokines in the dorsal (DH) and ventral (VH) hippocampus as compared with the neocortex, as well as changes in blood levels. The DH and VH responded specifically to proinflammatory stress: neurological inflammation developed more quickly in the DH, while corticosterone accumulation occurred more quickly in the neocortex and VH; functionally (in terms of the state of synaptic plasticity and the phenomenon of in vivo long-term potentiation), the DH suffered first, impairments then spreading to the VH.
Keywordsproinflammatory stress neuroplasticity dorsal hippocampus ventral hippocampus lipopolysaccharide corticosterone proinflammatory cytokines
Unable to display preview. Download preview PDF.
- Caudal, D., Jay, T., and Godsil, B., “Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels,” Front. Behav. Neurosci., 29, 8–19 (2014).Google Scholar
- Chung, D. W., Yoo, K. Y., Hwang, I. K., Kim, D. W., Chung, J. Y., Lee, C. H., Choi, J. H., Choi, S. Y., Youn, H. Y., Lee, I. S., and Won, M. H., “Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus,” Cell. Mol. Neurobiol., 30, 531–541 (2010).CrossRefGoogle Scholar
- Gulyaeva, N. V., “Effects of stress factors on the functioning of the hippocampus in the adult body: molecular-cellular mechanisms and the dorsoventral gradient,” Ros. Fiziol. Zh. im. I. M. Sechenova, 99, 3–16 (2013).Google Scholar
- Gwosdow, A. R., Kumar, M. S., and Bode, H. H., “Interleukin 1 stimulation of the hypothalamic-pituitary-adrenal axis,” Am. J. Physiol., 258, 65–70 (1990).Google Scholar
- Kelly, A., Vereker, E., Nolan, Y., Brady, M., Barry, C., Lo, C., Mills, K., and Lynch, M., “Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus,” J. Biol. Chem., 278, 19453–19462 (2003).CrossRefGoogle Scholar
- Maggio, N., Shavit-Stein, E., Dori, A., Blatt, I., and Chapman, J., “Prolonged systemic infl ammation persistently modifi es synaptic plasticity in the hippocampus: modulation by the stress hormones,” Front. Mol. Neurosci., 4, 6–46 (2013).Google Scholar