Dispersion analysis of niosomes different composition

  • Elena Igorevna DiskaevaEmail author
  • Olga Vladimirovna Vecher
  • Igor Alexandrovich Bazikov
  • Alexandr Nikolaevich Maltsev
Research Paper


The aim of this investigation was to study the variability of solutions of niosomes of various compositions under the influence of heating. For the analysis, the methods of scanning electron microscopy and processing of granulometric data were used. Experimental data on the sizes of niosomal vesicles of different compositions were statistically processed and interpreted from the point of view of the possibility of using a temperature factor to control the dispersion of the system. It has been shown that niosomes prepared on the basis of a nonionic surfactant, which is a group of dimethiconecopolyol substances that are esters of the polyethylene glycol and polydimethylsiloxane (PDMS) of the posterior bone, are more sensitive to the temperature factor, compared to niosomes based on sorbitan monostearate. So, for the first sample, the median size changed from 125 to 85 nm, and for the second sample from 790 to 560 nm. The data obtained made it possible to draw a conclusion about the relationship between the value of the specific surface calculated from the particle size distribution and the aggregative stability of niosomal dispersion.


Niosome Nonionic surfactant vesicles Particle size distribution Dispersity Stability Pharmaceutical applications 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. Bayindir ZS, Yuksel N (2010) Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery. J Pharm Sci 99:2049–2060. CrossRefGoogle Scholar
  2. Bazikov I.A., Omelyanchuk P.A. (2008) The method of delivery of biologically active substances with the help of niosomes. RF patent 2320323Google Scholar
  3. Dharashive VM, Yelam KVN, Devne SS (2015) Niosomes: as a targeted drug delivery system. Int J Res Pharm Chem 5(4):582–589Google Scholar
  4. Diskaeva EI, Vecher OV, Altakhov AS (2017) Statistical analysis of particle sizes of niosomal dispersion at different temperatures. Success Mod Sci Educ 5(2):170–173Google Scholar
  5. Diskaeva EI, Vecher OV, Bazikov IA, Vakalov DS (2018) Particle size analysis of niosomes as a function of temperature. Nanosyst Phys Chem Math 9(2):290–294CrossRefGoogle Scholar
  6. Maryam Homaei (2016) Preparation and characterization of giant niosomes. GothenburgGoogle Scholar
  7. Kovalev DA, Pisarenko SV, Ashhimina MA, Kulichenko AN (2012) Design and characterization of niosome microvesicles for encapsulating ofloxacin based on sorbitan monostearate. Biotechnology 6:23–31Google Scholar
  8. Kumar GP, Rajeshwarrao P (2011) Nonionic surfactant vesicular system for effective drug delivery – an overview. Acta Pharm Sin B 1(4):208–219. CrossRefGoogle Scholar
  9. Pestrikova NV, Karpov EM, Mazina NK (2009) Modern aspects of the creation of dosage forms as a prerequisite for the development of new pharmacotherapeutic technologies. Vyatskii Med Bull 2-4:26–30Google Scholar
  10. Petropavlovskaya VB, Novichenkova ТB, Belov VV, Buryanov AF (2013) Granulometric composition as a criterion for regulating the properties of disperse systems. Scientific and technical and production magazine “Building Materials” pp 64–65Google Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Elena Igorevna Diskaeva
    • 1
    Email author
  • Olga Vladimirovna Vecher
    • 1
  • Igor Alexandrovich Bazikov
    • 1
  • Alexandr Nikolaevich Maltsev
    • 1
  1. 1.Stavropol State Medical UniversityStavropolRussia

Personalised recommendations