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Dispersion analysis of niosomes different composition

  • Elena Igorevna DiskaevaEmail author
  • Olga Vladimirovna Vecher
  • Igor Alexandrovich Bazikov
  • Alexandr Nikolaevich Maltsev
Research Paper
  • 32 Downloads

Abstract

The aim of this investigation was to study the variability of solutions of niosomes of various compositions under the influence of heating. For the analysis, the methods of scanning electron microscopy and processing of granulometric data were used. Experimental data on the sizes of niosomal vesicles of different compositions were statistically processed and interpreted from the point of view of the possibility of using a temperature factor to control the dispersion of the system. It has been shown that niosomes prepared on the basis of a nonionic surfactant, which is a group of dimethiconecopolyol substances that are esters of the polyethylene glycol and polydimethylsiloxane (PDMS) of the posterior bone, are more sensitive to the temperature factor, compared to niosomes based on sorbitan monostearate. So, for the first sample, the median size changed from 125 to 85 nm, and for the second sample from 790 to 560 nm. The data obtained made it possible to draw a conclusion about the relationship between the value of the specific surface calculated from the particle size distribution and the aggregative stability of niosomal dispersion.

Keywords

Niosome Nonionic surfactant vesicles Particle size distribution Dispersity Stability Pharmaceutical applications 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Elena Igorevna Diskaeva
    • 1
    Email author
  • Olga Vladimirovna Vecher
    • 1
  • Igor Alexandrovich Bazikov
    • 1
  • Alexandr Nikolaevich Maltsev
    • 1
  1. 1.Stavropol State Medical UniversityStavropolRussia

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