pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release
- 158 Downloads
Stimuli-responsive polymeric micelles as a drug delivery vehicle have made important contributions to the development of controllable drug release. Here we develop pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release. Polymeric micelles in nano-sized spherical shape (about 140 nm) were mediated via hydrogen-bonding interaction between phenol groups of 4,4′-(1,2-diphenylethene-1,2-diyl)diphenol (TPE-2OH) and amine groups of poly(ethylene glycol)-block-linear polyethylenimine-block-poly(ε-caprolactone) (PEG-PEI-PCL). The results show that polymeric micelles are pH-responsive with turn-on fluorescence and sustained drug release inside cells, which has hope in simultaneously achieving cell imaging and cancer therapy.
KeywordspH-responsive polymeric micelles Hydrogen-bonding interaction Aggregation-induced emission Drug release Self-assembly Biomaterials Nanomedicine
This work was financially supported by the National Natural Science Foundation of China (Nos. 21603196, 51703209, and 21525523), the Natural Science Foundation of Hubei Province (2017CFB217), and the Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) (Nos. CUG170601 and CUGL170406).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interest.
- Bains A, Wulff JE, Moffitt MG (2016) Microfluidic synthesis of dye-loaded polycaprolactone-block-poly (ethylene oxide) nanoparticles: insights into flow-directed loading and in vitro release for drug delivery. J Colloid Interface Sci 475:136–148. https://doi.org/10.1016/j.jcis.2016.04.010 CrossRefGoogle Scholar
- Dai Y, Zhang XJ, Zhuo RX (2016b) Amphiphilic linear-hyperbranched polymer poly(ethylene glycol) -branched polyethylenimine-poly(ε-caprolactone): synthesis, self-assembly and application as stabilizer of platinum nanoparticles. Polym Int 65:691–697. https://doi.org/10.1002/pi.5118 CrossRefGoogle Scholar
- Kuang HH, Wu SH, Meng FB, Xie ZG, Jing XB, Huang YB (2012) Core-crosslinked amphiphilic biodegradable copolymer based on the complementary multiple hydrogen bonds of nucleobases: synthesis, self-assembly and in vitro drug delivery. J Mater Chem 22:24832–24840. https://doi.org/10.1039/c2jm34852g CrossRefGoogle Scholar
- Luo JD , Xie Z, Lam JWY, Cheng L, Tang BZ, Chen H, Qiu C, Kwok HS, Zhan X, Liu Y, Zhu Det al. (2001) Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole Chem Commun:1740–-1741 doi: https://doi.org/10.1039/b105159h
- Parrott EPJ, Tan NY, Hu RR, Zeitler JA, Tang BZ, Pickwell-MacPherson E (2014) Direct evidence to support the restriction of intramolecular rotation hypothesis for the mechanism of aggregation-induced emission: temperature resolved terahertz spectra of tetraphenylethene. Mater Horiz 1:251–258. https://doi.org/10.1039/c3mh00078h CrossRefGoogle Scholar
- Zhang XJ, Zhang ZG, Su X, Cai MM, Zhuo RX, Zhong ZL (2013) Phenylboronic acid-functionalized polymeric micelles with a HepG2 cell targetability. Biomaterials 34:10296–10304. https://doi.org/10.1016/j.biomaterials.2013.09.042 CrossRefGoogle Scholar