Shape controlled quantum dot (QD)-decorated-mesoporous SiO2 (m-SiO2/QD) hollow particles for photodynamic therapy
- 133 Downloads
This work reported a novel kind of CdTe quantum dot (QD) decorated mesoporous SiO2 (m-SiO2/QD) hybrid hollow nanoparticles for carrying photodynamic therapy (PDT) reagent. Both rod-like and spherical nanoparticles were prepared by using different shaped templates. Due to the porous shell and hollow interior, the hybrid m-SiO2/QD hollow nanorod with 360 nm long and 120 nm in diameter was selected for carrying zinc(II) phthalocyanine (ZnPc) photosensitizing molecules (61 mg/g) since the generated reactive 1O2 could be easily delivered out of the hollow particles through the porous shell (BET area 251 cm2/g). It was found that the m-SiO2/QD-ZnPc hollow nanorods exhibited a good PDT activity and showed effective photocytotoxicity for the cancer cells. Because of the porous nature, fluorescence characteristic, and excellent storage ability, the m-SiO2/QD hybrid hollow particles possessed broad potential in the fluorescent labeled PDT.
KeywordsHollow Porous Fluorescence SiO2 Photodynamic therapy (PDT)
Financial supports were from the National Natural Science Foundation of China (Grant Nos. 21205026), Key Project of Natural Science Research of Universities in Anhui Province (KJ2018A0550), and the Fundamental Research Funds for the Central Universities.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Kim S, Ohulchanskyy TY, Pudavar HE, Pandey RK, Prasad PN (2007) Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. J Am Chem Soc 129:2669–2675CrossRefGoogle Scholar
- Tuncel S, Dumoulin F, Gailer J, Sooriyaarachchi M, Atilla D, Durmus M, Bouchu D, Savoie H, Boyle RW, Ahsen V (2011) A set of highly water-soluble tetraethyleneglycol-substituted Zn(II) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity. Dalton Trans 40:4067–4079CrossRefGoogle Scholar