Electropreconcentration of nanoparticles using a radial micro-nanofluidic device
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We have developed a radial silicon micro-nanofluidic device in order to investigate strong nanoparticles electropreconcentration. The device is called “ring like” device and exhibits a circular micro-nanojunction. Hundred-nanometer-deep radial nanochannels were fabricated using standard photolithography and etching techniques. Ion permselectivity is one of the major proprieties of nanofluidic devices. Within the influence of an electric field through an ion-selective nanochannel, nanoparticle repulsion and concentration appear at the anodic and cathodic side, respectively. Here, the cathodic preconcentration is exploited to enriched 50-nm nanoparticles samples. Up to 800, enrichment factor is reached in 1 h of experiment. This scheme could be useful for the enrichment of bionanoparticles (such as viruses or exosomes for instance) which can be critical for several biomedical applications.
KeywordsRadial nanochannels Electropreconcentration Nanobeads Electrophoresis Biomedical applications
This work was supported by the Department of Micro Technologies for Biology and Healthcare of the Commissariat à l’Energie Atomique (CEA). This work has also been performed with the help of the “Plateforme Technologique Amont” de Grenoble, with the financial support of the “Nanosciences aux limites de la Nanoélectronique” Foundation.
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