, Volume 184, Issue 1, pp 97–105 | Cite as

Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review

  • Zimeng You
  • Xiaoxiao Yang
  • Jianbin Yu
  • Jiangan ZhangEmail author
  • Yuping RanEmail author
Original Paper


Chromoblastomycosis is found worldwide with higher incidence in tropical and subtropical regions. Fonsecaea spp. is one of the major causative agents of this disease. First case of chromoblastomycosis due to Fonsecaea nubica in Northern China is reported in a 75-year-old Chinese male. We firstly summarized molecular identification methods of Fonsecaea spp. and all the strains of F. nubica reported in the literature. Sequencing of internal transcribed spacer alone and/or combined with actin (ACT1), partial cell division cycle (CDC42) and partial beta-tubulin (BT2) were most commonly used to identify species, while lactase (Lac), homogentisate (HmgA) and polyketide synthase (PKS1) were also used in some cases. Most strains were isolated from South America and Eastern China. Five clinical cases of chromoblastomycosis due to F. nubica from Asia and Europe were also reviewed. All the five patients were male, over 30 years old, and their lesions occurred after trauma.


Chromoblastomycosis Fonsecaea nubica Species identification Molecular methods 



The authors thank Sushmita Pradhan (Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China) who corrected the English grammar of the article.

Compliance with Ethical Standards

Conflict of interest

All authors declare no conflict of interest.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Dermatovenereology, West China HospitalSichuan UniversityChengduChina
  2. 2.Department of Dermatology, First Affiliated HospitalZhengzhou UniversityZhengzhouChina

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