Successful Treatment of Eczema-Like Mucormycosis in a Child by Combination of Intravenous Drip and Percutaneous Injection Amphotericin B

  • Mei-hua Fu
  • Jia Liu
  • Guan-zhao Liang
  • Cheng-rang Li
  • Xiao-mei Zhu
  • Le Wang
  • Hao Chen
  • Wen-long Hu
  • Gui-xia Lv
  • Wei-da LiuEmail author
Original Paper


We report a case of eczema-like cutaneous mucormycosis caused by Rhizopus arrhizus. A 4-year-old child was presented to our hospital with a history of gradually enlarging papule and plaque in the periumbilical area for nearly 4 years since 2 weeks after his birth, and it has been misdiagnosed as eczema for nearly 3 years. Based on histopathology examination, the fungus culture test and DNA sequencing, it was revealed that R. arrhizus should be the responsible fungus for skin infection. The patient was successfully cured by combination of intravenous drip and percutaneous injection amphotericin B for nearly 3 months, and no recrudescence was seen during a follow-up of 6-month observation.


Mucormycosis Rhizopus Child Eczema-like 



This study was funded by Special Program for Basic work of science and technology, funded by the Ministry of Science and Technology of China (2013FY113700), supported by National Natural Science Foundation of China (81471905) and was funded by the Chinese Academy Medical Sciences Initiative for Innovative Medicine (2016-I2M-3-021).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2019

Authors and Affiliations

  • Mei-hua Fu
    • 1
  • Jia Liu
    • 1
  • Guan-zhao Liang
    • 1
  • Cheng-rang Li
    • 2
  • Xiao-mei Zhu
    • 4
  • Le Wang
    • 3
  • Hao Chen
    • 4
  • Wen-long Hu
    • 5
  • Gui-xia Lv
    • 1
  • Wei-da Liu
    • 1
    Email author
  1. 1.Department of Mycology, Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingChina
  2. 2.Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingChina
  3. 3.Department of Cosmetic Laser Surgery, Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingChina
  4. 4.Department of Pathology, Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingChina
  5. 5.Division of Sexually Transmitted Disease Epidemiology, Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingChina

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