, Volume 183, Issue 6, pp 941–949 | Cite as

Infections Caused by Fusarium Species in Pediatric Cancer Patients and Review of Published Literature

  • Mariana Volpe Arnoni
  • Claudete Rodrigues Paula
  • Marcos Ereno Auler
  • Cirilo Cesar Naozuka Simões
  • Shirley Nakano
  • Maria Walderez Szeszs
  • Márcia de Souza Carvalho Melhem
  • Virgínia Bodelão Richini Pereira
  • Hans Garcia Garces
  • Eduardo Bagagli
  • Eriques Gonçalves Silva
  • Melissa Ferreira de Macêdo
  • Luciana da Silva RuizEmail author
Short Communication


Fusarium species have emerged as responsible for a broad spectrum of infections, including superficial, locally invasive and disseminated ones, especially in the hospital environment. Since there are few reports of invasive and disseminated fusariosis in children, the aim of this study was to report four cases of nosocomial infection caused by this microorganism in children with cancer hospitalized in a public children’s hospital located in Brazil. Two of these patients were female and two were male. All patients presented febrile neutropenia, while three patients had acute lymphocytic leukemia and one patient had Wilms’ tumor as underlying disease. In two cases, fungi were isolated from blood and identified as Fusarium oxysporum species complex after phenotypic and genotypic studies, while in two other cases fungi were isolated from skin biopsies and identified as Fusarium solani species complex. One patient died 12 days after the onset of cutaneous lesions. All isolates, after susceptibility testing, presented high levels of minimum inhibitory concentration for itraconazole, voriconazole and amphotericin B. Considering the emergence of filamentous fungi as etiologic agents of nosocomial infections, health professionals should be aware of the problems these infections, especially fungal ones, may cause to debilitated patients.


Fusarium spp. Children Cancer Nosocomial infection 



We would like to thank “Fundação de Amparo à Pesquisa do Estado de São Paulo” (Fapesp - 2014/16507-0) for financial support and Letícia Campos for English review.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Mariana Volpe Arnoni
    • 1
  • Claudete Rodrigues Paula
    • 2
  • Marcos Ereno Auler
    • 3
  • Cirilo Cesar Naozuka Simões
    • 1
  • Shirley Nakano
    • 1
  • Maria Walderez Szeszs
    • 4
  • Márcia de Souza Carvalho Melhem
    • 4
  • Virgínia Bodelão Richini Pereira
    • 5
  • Hans Garcia Garces
    • 6
  • Eduardo Bagagli
    • 6
  • Eriques Gonçalves Silva
    • 2
  • Melissa Ferreira de Macêdo
    • 1
  • Luciana da Silva Ruiz
    • 5
    • 7
    Email author return OK on get
  1. 1.Hospital Infantil Darcy VargasSão PauloBrazil
  2. 2.Faculdade de OdontologiaUniversidade de São Paulo (USP)São PauloBrazil
  3. 3.Departamento de FarmáciaUniversidade Estadual do Centro-Oeste do Paraná (UNICENTRO)GuarapuavaBrazil
  4. 4.Secção de MicologiaInstituto Adolfo Lutz (IAL)São PauloBrazil
  5. 5.Núcleo de Ciências BiomédicasInstituto Adolfo Lutz (IAL), CLR IIBauruBrazil
  6. 6.Departamento de Microbiologia e ImunologiaUniversidade Estadual Paulista (UNESP)BotucatuBrazil
  7. 7.Instituto Adolfo Lutz - Rua Rubens ArrudaBauruBrazil

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