Abnormal vitamin D and lipid profile in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients
The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease of host-HTLV-1 interactions. In many virus-associated diseases and multiple sclerosis, the importance of vitamin-D and lipid profile has been demonstrated, thus similarly, their impacts were evaluated in HAM/TSP patients, in this study. Vitamin D and lipid profile were assessed in 120 healthy subjects (HSs), along with a proviral load (PVL) in 91 HAM/TSPs and 169 HTLV-1 carriers (ACs). The mean level of triglyceride and LDL in the HAM/TSPs were higher than HSs (P = 0.008 and 0.008, respectively), but no significant difference has been found between ACs and HSs. However, the level of HDL and vitamin-D in the HAM/TSP subjects were lower than HSs (P = 0.01 and P = 0.006, respectively). In HTLV-1 infected subjects, PVL was statistically associated with cholesterol (R = 0.24, P = 0.038), triglycerides (R = 0.26, P = 0.01) and HDL (R = 0.28, P = 0.001), and in HAM/TSPs there was a strong association between the severity of the disease, as determined by the OMDS and cholesterol (P = 0.01). Furthermore, in the HAM/TSPs, positive correlations between vitamin-D and age (R = 0.23, P = 0.028) and triglycerides (R = 0.38, P = 0.001) were found, also a significant correlation between PVL and LDL (R = 0.21, P = 0.001) and a weak correlation between PVL and OMDS (R = 0.4, P = 0.07) were noted. However, there was no correlation between PVL and urinary disturbance. Furthermore, PVL range of more than 600 copies/104 lymphocytes had a strong correlation with OMDS (P = 0.05), but not with urinary disturbance. It’s more likely that HAM/TSP patients have an imbalanced lipid profile and low levels of vitamin D and may represent a potentially useful target for intervention in HTLV-1 associated diseases.
KeywordsHTLV-1 HAM/TSP Vitamin D Lipid profile Triglycerides Cholesterol LDL HDL
Concept and design of study or acquisition of data or analysis and interpretation of data; SAR, MD, AM, SAG. Drafting the article or revising it critically for important intellectual content; RD, MM, HRJ, SAG. Final approval of the version to be published; RB, SAR. Willingness to assume responsibility of the study. SAR.
This study was financially supported by Vice Chancellor for Research and Technology, Mashhad University of Medical Sciences, Mashhad, Iran, under Grant [MUMS: 1395374].
Compliance with ethical standards
Conflict of interest
All the authors declared that they have no conflict of interest.
- 3.Valenti L, Pulixi EA, Arosio P, Cremonesi L, Biasiotto G, Dongiovanni P, Maggioni M, Fargion S, Fracanzani AL (2007) Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica 92(8):1037–1042CrossRefGoogle Scholar
- 6.Selvaraju R, Raman RG, Narayanaswamy R, Valliappan R, Baskaran R (2009) Trace element analysis in hepatitis B affected human blood serum by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). Rom J Biophys 19:35–42Google Scholar
- 14.Rafatpanah H, Rezaee A, Etemadi MM, Hosseini RF, Khorram B, Afsahr L, Taylor G, Mokhber N, Mahmoudi M, Abbaszadegan MR, Foroghipor M, Hashemi P, Amiri A, Tehrani M, Azarpazhooh A, Azarpazhooh MR (2012) The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran. J Neuroimmunol 250(1–2):87–93CrossRefGoogle Scholar
- 15.Rafatpanah H, Hedayati-Moghaddam MR, Fathimoghadam F, Bidkhori HR, Shamsian SK, Ahmadi S, Sohgandi L, Azarpazhooh MR, Rezaee SA, Farid R, Bazarbachi A (2011) High prevalence of HTLV-I infection in Mashhad, Northeast Iran: a population-based seroepidemiology survey. J Clin Virol 52(3):172–176CrossRefGoogle Scholar
- 17.Hedayati MMR (2013) Seroepidemiology of human T-cell lymphotropic virus type 1 infection in Iran: an overviewGoogle Scholar
- 18.Andrade RG, Goncalves Pde C, Ribeiro MA, Romanelli LC, Ribas JG, Torres EB, Carneiro-Proietti AB, Barbosa-Stancioli EF, Martins ML (2013) Strong correlation between tax and HBZ mRNA expression in HAM/TSP patients: distinct markers for the neurologic disease. J Clin Virol 56(2):135–140CrossRefGoogle Scholar