Overview of Staphylococcus epidermidis cell wall-anchored proteins: potential targets to inhibit biofilm formation

  • Silvestre Ortega-Peña
  • Sergio Martínez-García
  • Sandra Rodríguez-Martínez
  • Mario E. Cancino-Diaz
  • Juan C. Cancino-DiazEmail author


Currently, the treatment of infections by Staphylococcus epidermidis (S. epidermidis) represents a challenge because some strains have multidrug-resistance to antimicrobial products (antibiotic and biocides) and can produce biofilms. These biofilms protect bacterial cells from both antimicrobials and the host immune response. Therefore, it is crucial to encourage research on the development of new treatments. One method is immunotherapy, targeting components of S. epidermidis, such as S. epidermidis surface (Ses) proteins. Ses is expressed constitutively in most strains, and they participate in biofilm formation. This review is an update on Ses, regarding their structure, biological function, their relationship with S. epidermidis biofilm formation, and its possible role as therapeutic targets to develop immunotherapeutic treatments to prevent infections by S. epidermidis.


Staphylococcus epidermidis Ses Biofilm Immunotherapy 



This work was supported by the SIP-Instituto Politécnico Nacional Mexico 20181167. SRM, MCCD, and JCCD appreciate the COFAA and EDI, Instituto Politécnico Nacional fellowships, and the support from Sistema Nacional de Investigadores, CONACyT.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of MicrobiologyEscuela Nacional de Ciencias Biológicas-Instituto Politécnico NacionalMexico CityMexico
  2. 2.Laboratory of InfectologyInstituto Nacional de Rehabilitación Luis Guillermo Ibarra IbarraMexico CityMexico
  3. 3.Department of Immunology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico NacionalMexico CityMexico

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