Circular RNAs in β-cell function and type 2 diabetes-related complications: a potential diagnostic and therapeutic approach

  • Hassan Ghasemi
  • Zolfaghar Sabati
  • Hamid Ghaedi
  • Zaker Salehi
  • Behnam AlipoorEmail author


Recent investigations have indicated that altered expression of non-coding RNAs (ncRNAs) could be associated with human diseases such as type 2 diabetes (T2D). Circular RNAs (circRNAs) are a new discovered class of ncRNAs with unique structural characteristics that involved in several molecular and cellular functions. Exploring of the circulating circRNAs as a reliable non-invasive biomarker for monitoring and diagnosing of human diseases has grown significantly. However, the molecular functions and clinical relevance of circRNAs are not yet well clarified in T2D. Accordingly, in this review, the involvement of circRNAs in the β-cell function and T2D-related complications is highlighted. The study also shed light on the possibility of using circRNAs as a biomarker for T2D diagnosis.


Non-coding RNAs Circular RNAs Complications Biomarkers Type 2 diabetes 



This work was financially supported by a grant (98U-567) from the Deputy of Research, Abadan Faculty of Medical Sciences.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Clinical BiochemistryAbadan Faculty of Medical SciencesAbadanIran
  2. 2.Student Research CommitteeAbadan Faculty of Medical SciencesAbadanIran
  3. 3.Department of Medical Genetics, Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Department of Radiation SciencesYasuj University of Medical SciencesYasujIran
  5. 5.Department of Laboratory Sciences, Faculty of ParamedicineYasuj University of Medical SciencesYasujIran

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