Erythrocyte binding ligand region VI specific IgA confers tissue protection in malaria infection
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A direct role for IgA either for elimination of malaria parasite or for improvement in tissue pathology has not been investigated in case of Malaria infection while IgG, IgE and IgM were all implicated in the adverse pathology. In this communication, we delineate further that Malaria specific IgA appears to be significant among individuals who had multiple episodes of infection. Interestingly, the IgA elicited by immunization of the homologous peptides derived from Plasmodium berghei ANKA have also resulted in protection of host from adverse lung pathology, while the parasite load is unaffected. The PfrVI immunized mice and mice infected with repeated cycles of ‘infection and recovery’, simulating an endemic like situation, have resulted in development of B cell population that secretes the IgA specific to this region VI. Summarily, our results suggest that the IgA specific to the malarial antigen can confer significant advantage to hosts in protecting the overall tissue pathology.
KeywordsPlasmodium falciparum EBA175-rVI Plasmodium berghei ANKA IgA Endemic population TGF-β
The authors thank Dr. Shekhar Mande for institutional assistance, Dr. Prakash Deshpande for providing us the endemic human sera samples. Financial assistance for the work is provided by Department of Biotechnology, Government of India (Grant No. BT/PR5492/MED/14/641/2004) through an intramural research of National Center for Cell Science, Pune, India. SD is an SRF of UGC India., AK SK and EM are recipients of SRF from CSIR, India.
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Conflict of interest
The authors declare that they have no conflict of interest.
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