Molecular Biology Reports

, Volume 46, Issue 3, pp 3349–3355 | Cite as

Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots

  • Gulten Tuncel
  • Sehime Gulsun Temel
  • Mahmut Cerkez ErgorenEmail author
Original Article


Vitamin D is an important molecule to keep teeth, bones and muscles healthy. It is obtained from diet, supplements and primarily from exposure to sunlight. In recent years, vitamin D deficiency is recognised as a worldwide health problem, which results in disturbances in mineral metabolism and skeletal problems. Deficiency might be caused due to sedentary lifestyle, insufficient diet, age as well as some polymorphisms in the VDR gene. In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants. The rs2228570 (FokI) variant but not others were shown to have a significant association with decreased serum vitamin D levels in the Turkish Cypriot population.


VDR Polymorphism Vitamin D deficiency Cyprus 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no affiliations with or involvement in any organization or entity with any financial or non-financial interest in the subject matter or materials discussed in this article.

Supplementary material

11033_2019_4796_MOESM1_ESM.docx (395 kb)
Supplementary material 1 (DOCX 395 kb)


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Medical Biology, Faculty of MedicineNear East UniversityNicosiaCyprus
  2. 2.Research Center of Experimental Health Sciences (DESAM)Near East UniversityNicosiaCyprus
  3. 3.Department of Medical Genetics, Faculty of MedicineUludag UniversityBursaTurkey
  4. 4.Department of Histology and Embryology, Faculty of MedicineUludag UniversityBursaTurkey

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