The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α

  • Xiao-Wei Zhao
  • Jing-Ping Zhou
  • Yu-Lan Bi
  • Jia-Ying Wang
  • Rui Yu
  • Chao Deng
  • Wei-Kang Wang
  • Xian-Zhen Li
  • Rui Huang
  • Jili Zhang
  • De-Tao TaoEmail author
Original Article


To study the role of MAPK signaling pathway in the development of Epithelial-mesenchymal transition in oral squamous cell carcinoma induced by inflammatory factor TNF-α. After the action of TNF-α, the expression of JNK, ERK, P38 in MAPK signaling pathway increased and the expression of E-cadherin, Claudin1 decreased significantly compared to the normal control group. After the addition of corresponding inhibitor, the expression of JNK, ERK, P38 decreased and the expression of E-cadherin, Claudin1 increased compared with TNF-α group. TNF-α regulated the role of EMT in promoting the invasion and metastasis of oral squamous carcinoma cells through MAPK signaling pathway.


Oral squamous cell carcinoma TNF-α EMT MAPK 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11033_2019_4772_MOESM1_ESM.doc (26 kb)
Supplementary material 1 (DOC 26 kb)


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Oral Diseases Research Centre, Department of Oral Medicine, College of Oral MedicineWannan Medical CollegeWuhuPeople’s Republic of China
  2. 2.Department of StomatologyYijishan Hospital of Wannan Medical CollegeWuhuPeople’s Republic of China

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