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Molecular Biology Reports

, Volume 46, Issue 2, pp 2221–2230 | Cite as

Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus

  • Mu-Yang Li
  • Xin-Ming Zhu
  • Xiao-Tian Niu
  • Xiu-Mei Chen
  • Jia-Xin Tian
  • Yi-Di Kong
  • Dong-Ming Zhang
  • Lei Zhao
  • Gui-Qin WangEmail author
Original Article
  • 90 Downloads

Abstract

The present study evaluated the effects of dietary Allium mongolicum Regel polysaccharide (AMRP) on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus. A basal diet was supplemented with AMRP at 0, 1, 1.5 or 2 g/kg feed for 56 days. After the 56 days feeding period, weight gain (WG), specific growth rate (SGR) and feed conversion ratio (FCR) were significantly increased or decreased (P < 0.05) by dietary AMRP, with the highest WG, SGR and the minimum FCR occurring in 1.5 g/kg AMRP group. Furthermore, AMRP supplementation conferred significant protective effects against LPS challenge by preventing alterations in the levels of complements 3 (C3) and complements 4 (C4), lysozyme, superoxide dismutase (SOD), glutathione-S-transferase (GST), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) while regulating the expression of immune-related genes including heat shock protein 70 (HSP70), heat shock protein 90 (HSP90), SOD, GST, IL-1 and TNF-α. Finally, AMRP supplementation significantly increased serum total protein, albumin and globulin concentrations and reduced mortality after LPS challenge. Taken together, our results suggest that the administration of AMRP could attenuate LPS-induced negative effects in C. argus, with 1.5 g/kg considered a suitable dose.

Keywords

Allium mongolicum Regel Growth Immune response Antioxidant response Channa argus 

Notes

Acknowledgements

The research was supported by the earmarked fund for Modern Agro-industry Technology Research System (CARS-46) and National Natural Science Foundation of China (No. 31372540).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.College of Animal Science and TechnologyJilin Agricultural UniversityChangchunChina
  2. 2.Ministry of Education Laboratory of Animal Production and Quality SecurityJilin Agricultural UniversityChangchunChina
  3. 3.Jilin Provincial Key Laboratory of Animal Nutrition and Feed ScienceJilin Agricultural UniversityChangchunChina

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