Molecular Biology Reports

, Volume 46, Issue 1, pp 1499–1510 | Cite as

Immune aspects of the bi-directional neuroimmune facilitator TRPV1

  • Yan-Ruide LiEmail author
  • Puneet GuptaEmail author


A rapidly growing area of interest in biomedical science involves the reciprocal crosstalk between the sensory nervous and immune systems. Both of these systems are highly integrated, detecting potential environmental harms and restoring homeostasis. Many different cytokines, receptors, neuropeptides, and other proteins are involved in this bidirectional communication that are common to both systems. One such family of proteins includes the transient receptor potential vanilloid (TRPV) proteins. Though much progress has been made in understanding TRPV proteins in the nervous system, their functions in the immune system are not well elucidated. Hence, further understanding their role in the peripheral immune system and as regulators of neuroimmunity is critical for evaluating their potential as therapeutic targets for numerous inflammatory disorders, cancers, and other disease states. Here, we focus on the latest advancements in understanding TRPV1 and TRPV2’s roles in the immune system, TRPV1 in neuroimmunity, and TRPV1’s potential involvement in anti-tumor therapy.


TRPV1 TRPV2 Neuroimmunity Anti-tumor therapy Capsaicin 



The authors express gratitude to Zhihua Li and Mingye Yan in their support of this project.

Author contributions

Y-RL and PG conceived and authored the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the review.


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© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.College of Life SciencesZhejiang UniversityHangzhouChina
  2. 2.Department of Microbiology, Immunology & Molecular GeneticsUniversity of CaliforniaLos AngelesUSA
  3. 3.School of Arts and SciencesSt. Bonaventure UniversityNew YorkUSA
  4. 4.School of Medicine and Health SciencesThe George Washington UniversityWashingtonUSA

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