Study of association between interleukin-8 − 845 T/C and + 781 C/T polymorphisms with periodontitis disease among population from Western Iran
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Periodontitis is a chronic inflammatory disease that influences the protective tissues of teeth. IL-8, a member of the chemokine super-family, plays vital roles in the pathogenesis of periodontitis with activation and migration of neutrophils in inflammatory regions. The purpose of present study was to evaluate the association of interleukin-8 − 845 T/C and + 781 C/T polymorphisms with periodontitis in an Iranian population. A total of 65 patients with periodontitis including 18 patients with chronic periodontitis and 47 patients with aggressive periodontitis and 55 controls were enrolled into our study. Interleukin-8 − 845 T/C and + 781 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. For + 781C/T locus, in the dominant genetic model there was a significant difference between TT vs. CC + CT genotypes that significantly had a protective role against periodontitis disease with a value of 0.38 (95% CI 0.16–0.90, p = 0.02). Also, the analysis of results showed a significant positive association between the distribution of IL-8 − 845 T/C alleles and the risk of periodontitis disease (χ2 = 6.2, p = 0.01) that presence of C allele of IL-8 − 845 increased the risk of periodontitis disease by 9.08-fold [OR 9.08 (95% CI 1.14–72.12, p = 0.03)]. In conclusion, our results demonstrate a positive association between distribution of IL-8 − 845 T/C alleles and risk of periodontitis disease.
KeywordsPeriodontitis Interleukin-8 Polymorphism − 845 T/C + 781 C/T
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
This study was approved by the Ethics Committee of Kermanshah University of Medical Sciences, Iran. All participants signed the informed consent form, in line with the principles of the Helsinki II declarations.
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