Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives

  • Shu-Guang Zhang
  • Chao-Gen Liang
  • Yue-Qing Sun
  • Peng Teng
  • Jia-Qun Wang
  • Wei-Hua ZhangEmail author
Original Article


We synthesized a series of novel pyrrole- and pyrazole-substituted coumarin derivatives and evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds 5g, 6a, 6b, 6c, 6d and 6h exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound 5g displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 µg/mL) than positive control Osthole (EC50 = 67.2 µg/mL).

Graphical abstract


Aminocoumarin derivatives Nitrogen-containing Synthesis Antifungal activity 



The authors are grateful to the Program of National Key R&D Program of China (2018YFD0200103) and the Fundamental Research Funds for the Central Universities (KYTZ 201604) for partially funding this work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11030_2019_9920_MOESM1_ESM.docx (3.4 mb)
Supplementary material 1 (DOCX 3444 kb)


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Shu-Guang Zhang
    • 1
  • Chao-Gen Liang
    • 1
  • Yue-Qing Sun
    • 1
  • Peng Teng
    • 1
  • Jia-Qun Wang
    • 1
  • Wei-Hua Zhang
    • 1
    Email author
  1. 1.Jiangsu Key Laboratory of Pesticide, College of SciencesNanjing Agricultural UniversityNanjingPeople’s Republic of China

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