One-pot solvent-free synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives using Fe3O4@nano-cellulose/TiCl as a bio-based and recyclable magnetic nano-catalyst

  • Sara AzadEmail author
  • Bi Bi Fatemeh Mirjalili
Original Article


The present study describes an efficient and environmentally benign protocol for the synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives. Synthesis is done by one-pot three-component condensation of 2-naphthol, formaldehyde, and primary amines in the presence of Fe3O4@nano-cellulose/TiCl as a bio-based magnetic nano-catalyst under solvent-free conditions at room temperature grinding. This green procedure offers the advantages of high yield, short reaction time, environmental friendliness, easy workup, simple magnetic recovery of the catalyst and its reusability up to ten times without significant loss of catalytic activity. The structure of products was approved by FT-IR, 1H-NMR, 13C-NMR spectroscopy.

Graphical abstract


1,3-Oxazines Magnetic nano-catalyst Fe3O4@nano-cellulose/TiCl Room temperature grinding 



The Research Council of Yazd University gratefully acknowledged for the financial support for this work.

Supplementary material

11030_2018_9884_MOESM1_ESM.docx (17 mb)
Supplementary material 1 (DOCX 17405 kb)


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Chemistry, College of ScienceYazd UniversityYazdIslamic Republic of Iran

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