A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines

  • Shanmugavel Uma Maheswari
  • Sundaravel Vivek Kumar
  • Shanmugam Muthusubramanian
  • Subbu Perumal
Original Article


A simple, efficient and green procedure for the synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines has been developed via a Krohnke-type one-pot three-component reaction of 2-[arylmethylidene]-3,4-dihydro-1(2H)-acridinones and (2-aryl-2-oxoethyl)pyridinium bromides in the presence of excess ammonium acetate in good yields under solvent-free conditions. Good functional group tolerance, high substrate scope and no column purification are the practical advantages of this methodology.

Graphical abstract


Multicomponent domino reaction Solvent-free reaction Green chemistry Dihydrobenzo[j][1,7]phenanthrolines MCRs 



SM acknowledges the award of Emeritus Scientist Scheme from CSIR, New Delhi.

Supplementary material

11030_2018_9847_MOESM1_ESM.docx (1.6 mb)
Supplementary material 1 (DOCX 1634 kb)


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shanmugavel Uma Maheswari
    • 1
    • 2
  • Sundaravel Vivek Kumar
    • 1
  • Shanmugam Muthusubramanian
    • 1
  • Subbu Perumal
    • 1
  1. 1.Department of Organic Chemistry, School of ChemistryMadurai Kamaraj UniversityMaduraiIndia
  2. 2.Centre of Research and P.G. Studies in ChemistryAyya Nadar Janaki Ammal CollegeSivakasiIndia

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